10 citations
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May 2007 in “Oncology Reports” This study found that increased metastatic ability in colorectal cancer in a rat model was linked to changes in expression of multiple genes, including TGF-beta, PDGFb, and Rho B.
24 citations
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November 2021 in “PLoS ONE” In this study, fractional laser treatment was observed to reverse age-related gene expression changes in skin and enhance dermal remodeling, further improved by multiple treatments.
4 citations
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July 2025 in “Frontiers in Immunology” This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.
1 citations
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October 2023 in “European journal of histochemistry” This study demonstrated that treating platelet-rich plasma with ozone or procaine in vitro led to distinct changes in platelet activity, significantly enhancing the release of platelet-derived factors without damaging the platelets, indicating potential for improved regenerative therapies.
December 2025 in “Scientific Reports” In this study, researchers observed that DHEA-induced PCOS rats experienced significant changes in gut microbiota and metabolic profiles, particularly affecting steroid and lipid metabolism, suggesting the gut-ovary axis may play a role in the pathogenesis of PCOS.
January 2025 in “Universidad de Córdoba Insitutional Repository (Universidad de Córdoba)” In this study, researchers observed that individuals with alopecia areata exhibited significant changes in scalp microbiota diversity and composition, which were linked to disease severity and inflammation markers, though it remains unclear if these microbial shifts are a cause or a result of hair loss.
47 citations
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June 2019 in “Nature Communications” This study found that self-noncoding dsRNA activates TLR3 to stimulate intrinsic retinoic acid synthesis, promoting new hair follicle formation in wounded mice and showing similar gene expression changes in humans treated with rejuvenation lasers.
41 citations
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June 2010 in “Journal of Investigative Dermatology” This study suggests that new cells are incorporated into the dermal papilla during the early anagen phase of the hair cycle, which may influence hair growth consistency and follicle size changes.
2 citations
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April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that skin surface lipids contain measurable mRNAs, providing a non-invasive way to study skin diseases, with specific gene expression changes observed in atopic dermatitis patients.
In this study, lower dihydrotestosterone and higher testosterone levels were linked to increased brain activation during response inhibition, although no behavioral changes were detected.
January 2024 in “GeroScience” This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.
7 citations
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November 2022 in “Communications biology” This study found that injecting keratin into the skin of mice promoted hair growth, potentially through keratin's interaction with hair-forming cells and changes in the microenvironment.
4 citations
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December 2021 in “Archivio italiano di urologia andrologia” This review found that patients taking antiandrogens, 5 alpha-reductase inhibitors, and spironolactone have an increased risk of developing gynecomastia, potentially due to hormonal changes.
1 citations
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May 2023 in “Journal of molecular evolution” This study explored the molecular biology of skin adaptations in pangolins, revealing that certain genes for lipid synthesis have inactive patterns, while others related to skin function remain intact, suggesting complex evolutionary changes in their skin physiology.
This study found that patients with androgenetic alopecia showed distinct scalp bacterial imbalances compared to healthy individuals, which were associated with unhealthy lifestyles. These microbial changes might contribute to follicular inflammation, potentially accelerating hair loss in these patients.
December 2025 in “Frontiers in Veterinary Science” In this study, researchers explored hair follicle development in Qianhua Mutton Merino sheep, identifying key genes like KRT27 and IGF-2 that impact this process, with findings suggesting significant molecular changes as sheep mature from newborn to one year old.
November 2025 in “Frontiers in Veterinary Science” In this study, feeding H-line chickens a diet with 1.0% tyrosine for 40 days significantly increased melanin deposition in feathers and revealed changes in gene expression related to melanin pathways, suggesting tyrosine's involvement in regulating feather color through the EDNRB2 regulatory network.
The researchers observed that in cichlid fishes with different dental structures, tooth replacement accelerated more than three times following tooth extraction, alongside distinct changes in gene expression and cellular interactions over one week, providing insights into tooth regeneration mechanisms in vertebrates.
January 2024 in “Wiadomości Lekarskie” This study highlights that restrictive abortion laws, financial barriers, and lack of sexual education are major issues in countries like Poland, the USA, and Italy, suggesting needed changes such as improved sex education, access to contraception, and international networks for legal abortion.
In this study, researchers found that alopecia areata is linked to immune cell activation against hair follicle autoantigens and is associated with heart changes and cardiac marker alterations in humans and mice.
22 citations
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September 2004 in “Journal of The European Academy of Dermatology and Venereology” Bimatoprost can cause longer, thicker, darker eyelashes and eyebrows.
7 citations
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May 2025 in “Stem Cell Research & Therapy” This review compiles EV proteomics data and reports that while MSC-derived EVs show promise in skin therapeutics, variability in protein cargo highlights the need for standardized methodologies in understanding process impacts.
26 citations
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December 1999 in “Journal of Investigative Dermatology” This study found that manipulating prolactin levels in New Zealand Wiltshire sheep induces wool follicle growth cycles, revealing gene expression changes that suggest roles for specific genes in follicle function.
18 citations
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August 2023 in “Journal of Cell Science” This review explores how metabolic changes drive cellular quiescence and considers potential applications in cancer treatment by manipulating these processes.
4 citations
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July 2024 in “Biomolecules” This review suggests systemic changes in polycystic ovary syndrome may increase the risk of neurodegeneration, potentially linking it to Alzheimer's disease through common pathways affecting tryptophan metabolism.
1 citations
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January 2023 in “Science Advances” This study found that bacterially induced metabolic changes in stem cells can enhance skin and hair follicle regeneration in both mice and humans, suggesting potential strategies for improving recovery after injury.
November 2022 in “Journal of Investigative Dermatology” This study found that different stressors causing premature senescence in fibroblasts resulted in distinct changes in lipid profiles, particularly sphingolipids, which may affect the behavior of senescent skin cells.
January 2022 in “Kafkas Universitesi Veteriner Fakultesi Dergisi” In this study, differences in protein expression related to twin lambing were identified in Tibetan sheep, providing insights into the reproductive performance and fertility improvement strategy for sheep in the Qinghai-Tibet Plateau.
114 citations
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February 2023 in “International Journal of Molecular Sciences” This review discusses the relationship between skin microbiome changes and conditions such as ageing and skin disease, emphasizing the need for further research, but reports no new findings.
12 citations
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March 2022 in “Frontiers in Nutrition” This review discusses the complex skin changes associated with obesity and the potential benefits of nutritional interventions for inflammatory skin diseases, without reporting new clinical results.