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In this study, researchers identified significant differences in protein expression patterns in scalps affected by central centrifugal cicatricial alopecia, notably upregulation of immune pathways and fibrosis markers and downregulation of metabolic proteins, suggesting unique disease mechanisms and potential therapeutic targets.

This study found that patients with frontal fibrosing alopecia showed significant alterations in protein expression in forehead corneocytes, suggesting the condition may have systemic implications beyond the scalp.

This review explores the complex, context-dependent roles of tumor-secreted proteins and suggests that some proteins traditionally seen as tumor-promotive may act as tumor-suppressors in different environments, emphasizing the influence of cell fitness and treatment exposure.

Alopecia totalis/universalis involves more intense immune activity and inflammation than patchy alopecia areata.

This review reports on the potential for deucravacitinib, an oral TYK2 inhibitor approved for psoriasis, to treat various immune-mediated diseases, with emerging research suggesting possible uses in neurodegenerative diseases and certain cancers.

This study found that proteomic analysis can distinguish hair samples across different ethnicities and body regions based on keratin protein levels, which may aid forensic hair identification.

This study found that dermal sheath stem cell characteristics are lost with aging in humans, affecting skin rejuvenation and structure, and identified specific proteins like Activin A influencing keratinocyte and fibroblast activity.

In this study on Angora rabbits, researchers identified genetic factors influencing wool fiber diameter by analyzing hair follicle proteins, highlighting keratin family members and other proteins as key contributors to fiber differences between coarse and fine wool.

In this study, researchers identified key miRNAs and target genes involved in hair follicle development in Merino sheep, providing insights that could aid in improving sheep breeding for wool quality.

This mini-review details how the SOX family of transcription factors contributes to cancer immune evasion by affecting antigen presentation, impacting the tumor's immunosuppressive environment, and regulating immune checkpoints, offering insights for developing novel immunotherapy strategies.

This study reported that supplementing rat hair follicle stem cells with chick embryo extract enhanced their migration and proliferation, possibly promoting differentiation toward Schwann cells.

In this study, researchers performed a genome-wide characterization of the Wnt gene family in domestic donkeys, identifying 19 genes and highlighting their evolutionary conservation among mammals, along with tissue-specific expression patterns potentially linked to reproductive regulation and tissue homeostasis.

This article outlines methods to study the skin and its molecular traits, focusing on interpretation and techniques applicable to mouse models, including diverse assays and approaches like electron microscopy and large-scale lipid analyses.

This study found that using a pharmacogenetic panel with 26 SNPs can improve treatment outcomes for androgenetic alopecia, as overall response rates to minoxidil, finasteride, and dutasteride were high, and specific genetic markers predicted poor responses to these drugs.

Milk-derived vesicles are promising for delivering drugs orally and treating various conditions.

This study provided the first proteome dataset for alopecia areata, revealing novel pathways in the disease mechanisms that may lead to new therapeutic targets.

This review discusses recent advances in understanding alopecia areata's disease mechanisms and highlights JAK molecules as promising therapeutic targets, but reports no new clinical results; controlled trials are needed.

This review highlights the pharmaceutical potential of secondary metabolites from Juniperus species, noting promising antitumor, antibacterial, and antiviral activities, but reports no new experimental findings.

This review discusses advanced techniques for investigating stem cell fate at the single-cell level, including lineage tracing, time-lapse imaging, and molecular profiling, but reports no new research results.

In this study, hair follicle germs containing vascular endothelial cells showed improved hair regeneration and morphogenesis-related gene expression in mice, suggesting a promising strategy for hair regenerative medicine.

This study found that hair proteomics may serve as a promising, non-invasive biomarker source for stress-associated psychopathology, showing high accuracy in distinguishing patients with non-suicidal self-injury disorder from healthy controls.

This study reports promising results for alopecia universalis treatment using a combination of systemic methotrexate and low-dose corticosteroids with topical minoxidil, though monitoring for side effects is necessary.

This review highlights the potential of extracellular vesicle-based therapies for treating various diseases, but it also notes challenges like the lack of regulatory guidelines that hinder their clinical development.

This review suggests that induced pluripotent stem cells (iPSCs) hold promise for treating chronic wounds, but further work is needed to address safety, efficacy, and translation from preclinical models to real-world applications.

In this study, differences in protein expression related to twin lambing were identified in Tibetan sheep, providing insights into the reproductive performance and fertility improvement strategy for sheep in the Qinghai-Tibet Plateau.

This study described a method using sodium dodecanoate and high levels of reductant to process hair shaft proteomes, allowing analysis of genetic, developmental, and forensic information beneficial to various scientific fields.

This study reported that machine learning analysis of protein profiles in hair segments achieved high accuracy in distinguishing women with non-suicidal self-injury disorder from healthy controls, suggesting hair proteomics as a promising non-invasive biomarker for stress-related psychopathology with potential clinical applications.

This review discusses the potential of extracellular vesicles from various sources as promising candidates for hair growth stimulation but notes that clinical trials are needed to confirm their effectiveness and safety.

This review assesses the potential of dutasteride as a promising treatment for ALS due to its reported neuroprotective, antioxidant, and anti-inflammatory effects, but emphasizes that clinical studies are needed for confirmation.

This study found that exosomes and secretome derived from rat hair follicle stem cells show promising potential for wound healing and tissue repair, demonstrating significant wound closure and suggesting their broader applicability in regenerative medicine.