December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that extracellular matrix scaffold membranes performed less effectively in wound healing for aged mice compared to younger ones, with senescent SPP1+ macrophages potentially hindering epidermal and fibroblast repair abilities.
April 2021 in “Arab Journal of Nuclear Sciences and Applications/Arab Journal of Nuclear Sciences and Applications ” This study found that repeated use of a protein hair conditioner, followed by hot air and gamma irradiation, may lower serum collagen I and increase heat shock protein concentrations in rats, suggesting potential cumulative risks.
This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.
March 2001 in “International Journal of Cosmetic Surgery and Aesthetic Dermatology” This article is a collection of book reviews in the International Journal of Cosmetic Surgery and Aesthetic Dermatology and presents no new clinical findings.
1 citations
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June 2025 in “Frontiers in Bioengineering and Biotechnology” This review examines glycopeptide hydrogels as biomimetic materials for tissue regeneration and other biomedical applications, describing their design, properties, and potential uses, and highlighting future advancements in replicating natural tissue environments for precision medicine.
June 2024 in “International journal of biological macromolecules” This study reports that beta-glucan hybrid hydrogels, reinforced with laponite nanoclay, showed promising results in rat models for managing hemorrhage and diabetic wound healing by enhancing hemostasis, reducing inflammation, and promoting faster wound closure and tissue regeneration.
March 2026 in “Journal of Biomedical Materials Research Part B Applied Biomaterials” This study found that a chitosan, chondroitin sulfate, and hyaluronic acid scaffold improved wound healing in rats by promoting immune-stromal interactions, reducing inflammation, and supporting tissue regeneration with ~91% wound closure by day 17 compared to ~63% in controls.
31 citations
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January 2011 in “Journal of Biomaterials and Nanobiotechnology” This paper describes the development of unique hydrogel skin scaffolds from plant-derived polysaccharide mixtures that may offer improved biocompatibility and mechanical properties for use in artificial skin.
January 2026 in “RSC Advances” This study found that the natural polymer-based hydrogel Gel/SA@PL released growth factors in a controlled way, which enhanced tissue regeneration and minimized scarring in the healing of diabetic wounds.
29 citations
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July 1991 in “Biochimica et Biophysica Acta (BBA) - General Subjects” Glycoproteins are present in the cell membranes of various keratin fibers.
June 2025 in “Materials Today Bio” In diabetic mice, this study reported that the multifunctional hydrogel CPGel achieved complete wound closure in 21 days, showing promise in improving chronic wound healing through antibacterial, antioxidative, and tissue regeneration properties.
262 citations
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May 2020 in “Advanced Functional Materials” This study demonstrated that a newly developed polypeptide-protein hydrogel with vascularization and antibacterial properties promoted tissue regeneration and hair follicle formation in infected wound healing.
479 citations
,
January 2005 in “BioEssays” This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.
425 citations
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January 2021 in “SN Applied Sciences” This article highlights the versatility and potential of alginate and its derivatives in tissue engineering applications, discussing their properties, modification techniques, and various uses in enhancing tissue healing, bone regeneration, and cell growth.
384 citations
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June 2005 in “Genes & development” This study found that stabilized beta-catenin is crucial for activating stem cell transition from quiescence to proliferation in hair follicles by influencing gene expression within the stem cell niche.
375 citations
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July 2006 in “Journal of Investigative Dermatology” This review discusses the brain-skin connection, the skin's role in stress response, and highlights unmet challenges in understanding stress-induced skin inflammation but reports no new experimental findings.
306 citations
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April 2019 in “International Journal of Molecular Sciences” This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.
305 citations
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March 2018 in “International journal of molecular sciences” In this review, the authors summarize classical and recent insights into the biology and treatment of hypertrophic scars and keloids, concluding that while understanding and strategies have advanced, effective prevention and treatments remain unsatisfactory.
299 citations
,
January 2018 in “Journal of Clinical Investigation” This review explores fibroblast heterogeneity in the mammalian dermis and suggests potential therapeutic applications by targeting fibroblast subtypes, but reports no new experimental results.
262 citations
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May 2017 in “Nanomedicine” This review examines recent advancements in electrospun nanofibers for wound healing applications, but reports no new experimental results, highlighting their potential in sutures, dressings, and skin regeneration.
252 citations
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February 2018 in “npj Regenerative Medicine” This review explores recent advances in understanding molecular mechanisms of tissue regeneration in mammals and suggests potential therapeutic targets, but it reports no new clinical results.
245 citations
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January 2018 in “Bone Research” This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.
233 citations
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February 2018 in “Polymers” This review examines the roles and benefits of chitosan in cosmetics and oral hygiene, highlighting its potential in the cosmeceutical market, but it reports no new results.
232 citations
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October 2015 in “International journal of molecular sciences” This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.
232 citations
,
June 2012 in “Cold Spring Harbor Perspectives in Biology” This review summarizes the roles of Wnt signaling in wound healing but presents no new clinical findings, suggesting potential for Wnt-based therapies to enhance tissue regeneration.
212 citations
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September 2015 in “Journal of Investigative Dermatology” This article presents a comprehensive guide for classifying human hair follicle cycle stages in vivo using scalp xenografts on immunocompromised mice, offering valuable resources for researchers in the field.
202 citations
,
August 2007 in “Biomaterials” This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.
191 citations
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February 2002 in “Archives of Dermatology” This review discusses herbal therapies for dermatologic disorders, focusing on those with scientific evidence of efficacy and common interactions, but reports no new clinical results.
179 citations
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April 2012 in “Nature Communications” This study demonstrates the potential of using bioengineered follicles from adult tissue-derived stem cells for fully functional hair regeneration, illustrating possible applications in organ replacement therapy.
178 citations
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August 2016 in “Advances in wound care” This article discusses advancements in understanding how skin stem cells and fibroblasts contribute to scar formation, highlighting current and potential therapies aimed at preventing or reducing scarring, yet notes that effective treatments without significant side effects are still lacking.