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Genetic mutations can affect female sexual development, requiring personalized medical care.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Human skin can make serotonin and melatonin.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Hair loss needs more research for better treatments.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Different PIN proteins affect plant root hair growth by changing how auxin is transported.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Olive oil compounds may help prevent cancer in animals, but human results are mixed.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.