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People with first-time vitiligo have lower levels of a certain brain protein compared to healthy individuals.

Cytochrome P-450 enzymes in the skin help break down various substances and could be targeted to treat skin conditions.

Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

mTORC1 activity is important for hair growth and color, and targeting it could help treat hair loss and greying.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

Hair follicle stem cells and mitochondria are key for hair growth, and targeting their activity could lead to new hair loss treatments.

Scarred skin in lichen planopilaris loses immune cells due to a decrease in a specific protein in skin cells.

Melanoma risk tools need improvement, certain gene mutations cause skin diseases and could be treated by targeting those mutations, skin wrinkling may relate to lung aging due to genetic factors, and oxidative stress affects hair loss but can be reduced in low oxygen.

AMF initially inhibits but later promotes citrus root hair growth by regulating auxin levels.

Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

The risk of skin tumors becoming malignant depends on the specific skin cell type affected.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Female pattern hair loss diagnosed by scalp appearance, treated with combined therapies and targeted approaches.

Patients with acanthosis nigricans often have insulin resistance and signs of increased male hormones, but treatment targeting these male hormones is generally ineffective.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

Nanotechnology improves hair care products by enhancing ingredient stability, targeting treatment, and reducing side effects, but more research on its toxicity is needed.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

Imiquimod cream activates hair follicle stem cells and causes early hair growth by changing immune cells and certain protein expressions.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.