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Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

The Rotterdam Study aims to understand various diseases in older adults.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Oestrogens are key for bone growth during puberty in both boys and girls.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.