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This literature review reports that multivitamin supplementation can enhance hair density and quality in people with suboptimal nutritional status but warns that excessive intake of certain vitamins and minerals may cause hair loss.

This study found that inhibiting class I histone deacetylases in postnatal mouse dermal cells preserved their ability to induce hair follicles during culture by increasing specific gene expressions and activating the Wnt signaling pathway.

This study found that the Foxn1(-/-) nude phenotype significantly influences epithelial progeny in skin, with notable changes in stem cell niches not achievable in other models.

This study found that the secretory profiles of adipose-derived stem cells vary between balding and non-balding scalp areas in androgenetic alopecia patients, suggesting involvement of angiogenic and inflammatory processes in the condition's development.

In this study, researchers used a CRISPR-based method to correct mutations in the COL7A1 gene in stem cells from RDEB patients, restoring normal collagen expression in engineered skin grafts in mice.

This study identified CD28 as a promising drug target for treating alopecia areata, using a multi-omics approach to highlight its role in immune regulation and linking it to favorable safety profiles, thus offering a strategy for autoimmune target discovery.

This study identified CD28 as a potential drug target in treating alopecia areata by linking immune signaling pathways to local inflammation, highlighting belatacept as a promising treatment option due to minimal adverse effects and providing insights into autoimmune target discovery.

This study found that subcutaneous adipose tissue-derived extracellular vesicles (AT-EVs) protect skin from photodamage by enhancing fibroblast proliferation and reducing oxidative stress compared to those from adipose-derived stem cells.

This study reported that the absence of Lsh in skin led to significant epidermal hyperplasia and altered gene expression, suggesting its crucial role in regulating epidermal proliferation, differentiation, and wound healing.

This review discusses the molecular mechanisms involved in hair follicle development and regeneration, highlighting findings from mouse genetic studies, and reports no new experimental results.

This study found that microwave-assisted Opuntia humifusa extract improved antioxidant and anti-inflammatory properties to counteract particulate matter's harmful effects on HaCaT keratinocytes.

This study suggests that an extract from Malva verticillata seeds could help treat hair loss by modulating the Wnt/β-catenin pathway in cultured human dermal papilla cells.

This study suggests that activating AMPK to phosphorylate ZDHHC13 may enhance MC1R function and reduce melanoma risk in individuals with red hair.

This study found that the CXXC5 protein is overexpressed in diabetic foot ulcer tissues, suppressing wound healing, and that the small molecule KY19334 accelerated healing in diabetic mice by activating the Wnt/β-catenin pathway.

This study found that both metformin and rosiglitazone improved ovulation and insulin sensitivity in women with PCOS, with rosiglitazone showing a more pronounced increase in adiponectin levels.

This study developed a nanoscale biomimetic matrix that effectively and stably expands human hair follicle stem cells, offering a new tool for hair follicle reconstruction research.

In this review, researchers highlighted that natural polyphenolics like flavonoids and resveratrol may help enhance testosterone production in aging males by boosting the expression of the Star gene in Leydig cells, potentially preventing age-related degenerative conditions linked to testosterone insufficiency.

This study found that Pomiferin may effectively stimulate extracellular matrix protein expression in skin and scalp models, with results comparable to retinol, suggesting potential as a topical treatment ingredient.

This study found that stem cell factor (SCF) improved wound healing in diabetic mice by enhancing stem cell recruitment and increasing key protein expressions involved in the healing process.

This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.

In this study, topical piperonylic acid was found to improve wound healing in mice by activating EGFR and modulating gene expression related to the healing process.

This study found that stimulating toll-like receptor 5 via mucosal delivery of a flagellin-containing fusion protein effectively extended lifespan and enhanced healthspan in mice, including improved bone density and cognitive capacity.

In this study, researchers developed gellan gum hydrogels functionalized with biomimetic peptides that create a supportive microenvironment for human dermal papilla cells, enhancing their hair-inductive capacity and ability to mimic hair morphogenesis-like events in vitro.

In this study, researchers developed a novel 3D bio-printed skin scaffold using exosomes from liver cells, which enhanced wound healing by promoting cell growth, angiogenesis, and reducing inflammation in large skin injuries, suggesting potential applications in treating chronic skin conditions.

This study introduced fibronectin nanogel microneedles (FNG MNs) that demonstrated improved tissue penetration and transdermal delivery, restoring skin homeostasis in a photoaged mouse model and enhancing collagen deposition and angiogenesis in a diabetic wound rat model.

This study designed fibronectin nanogel microneedles, reporting their potential to enhance tissue repair by improving collagen organization, reducing inflammation, and promoting angiogenesis in both photoaged and diabetic wound models.

This study found that measuring stress biomarkers in hair could be an effective and simpler method for assessing chronic stress in rats, potentially offering a novel alternative to serum tests with biomarkers including sodium, calcium, and cortisol.

Enhancing Tregs can protect against alopecia areata.

In this study, peptide nanofiber gels RG and RJ significantly accelerated the healing of deep second-degree burn wounds in vivo, with greater wound closure rates and enhanced tissue regeneration compared to controls, attributed to increased angiogenesis and reduced systemic inflammation.

In this chicken embryo study, E40 hemp seed callus-derived exosomes counteracted DHT-induced inhibition of hair follicle development, suggesting potential for alopecia treatment and hair follicle regeneration.