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Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Post-finasteride syndrome's existence is uncertain; more research needed.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

CAP1 helps Arabidopsis plants grow better under ammonium stress.

Biotin helps regulate proteins in the blood, which may explain its role in hair growth.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Two drugs, finasteride and minoxidil, are approved for hair loss treatment, but new therapies are being developed.

FLRG and follistatin have different roles in wound healing.

Plet-1 protein helps hair follicle cells move and stick to tissues.

The hexosamine pathway helps protect skin cells from stress and may improve skin and hair health.

GALT5 and GALT2 are important for plant growth and development because they help with protein glycosylation.

A new gene, mrp4, is found in mice and may play a unique role in hair follicle development in tails and ears.

The hexosamine pathway helps maintain healthy skin by affecting the skin's structure and possibly increasing hair follicle stem cells.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Two distinct pathways direct proteins to vacuoles in Arabidopsis, affecting root hair growth and protein targeting.

Researchers found four key proteins that affect the development of a specific hair type in Yangtze River Delta white goats.

The PTGER2 gene is highly active in Cashmere goat skin and its activity changes with the hair growth cycle.

Researchers found 15 new genetic links to skin traits in Japanese women.

A new mRNA variant of the SCF gene in sheep skin produces a shorter, different protein.

The WIF1 gene is crucial for hair growth in Angora rabbits.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.