34 citations
,
February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.
15 citations
,
July 2008 in “Journal of Dermatological Science” This study found that ephrin-A3 accelerates hair follicle development and increases hair follicle density in neonatal mice, suggesting its involvement in hair growth regulation.
8 citations
,
July 2019 in “Cell Proliferation” In this study, researchers developed a chemical cocktail and suspension culture method to transform human dermal fibroblasts into dermal papilla-like cells capable of inducing hair follicle formation in vitro and in vivo.
3 citations
,
October 2007 in “Expert Review of Dermatology” This review discusses the biological and cosmetic aspects of hair aging and reports no new clinical results; it highlights current treatments and future research directions to address both aging factors.
2 citations
,
May 2017 in “Springer eBooks” Pregnancy can cause skin changes and affect existing skin conditions, with limited treatment options due to the need for fetal safety.
April 2015 in “Plastic and Reconstructive Surgery” This article discusses the role of the American Society of Plastic Surgeons in plastic and reconstructive surgery education but presents no new research findings.
68 citations
,
August 2014 in “Stem Cells Translational Medicine” This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.
53 citations
,
January 2009 in “Journal of Investigative Dermatology” In this study, UVB irradiation of organ-cultured human anagen hair follicles in vitro reduced hair elongation and increased cell death, affecting hair growth and regulatory processes.
25 citations
,
August 2010 in “Acta Biomaterialia” This study achieved a first by successfully forming large quantities of dermal papilla spheroidal microtissues, which retained their hair induction potential, using a micropatterned culture system.
11 citations
,
November 2012 in “Seminars in Cutaneous Medicine and Surgery” This review summarizes current understanding and genetic insights into androgenetic alopecia, female pattern hair loss, and alopecia areata, noting the potential future role of molecular diagnostics, but it reports no new clinical results.
1160 citations
,
November 2018 in “Physiological Reviews” This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
480 citations
,
August 2014 in “Nature Biotechnology” This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.
425 citations
,
January 2021 in “SN Applied Sciences” This article highlights the versatility and potential of alginate and its derivatives in tissue engineering applications, discussing their properties, modification techniques, and various uses in enhancing tissue healing, bone regeneration, and cell growth.
403 citations
,
December 2018 in “Cell stem cell” This study suggests that phenotypic plasticity, including processes like dedifferentiation and transdifferentiation, plays a crucial role in cancer initiation, progression, and therapy resistance, broadening our understanding of cancer dynamics and potential treatment strategies.
363 citations
,
March 2017 in “Nature Communications” This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.
308 citations
,
September 2010 in “Nucleic acids research” This study found that induced expression of mir-302 can reprogram human hair follicle cells into induced pluripotent stem cells through a novel epigenetic mechanism involving global demethylation.
305 citations
,
March 2018 in “International journal of molecular sciences” In this review, the authors summarize classical and recent insights into the biology and treatment of hypertrophic scars and keloids, concluding that while understanding and strategies have advanced, effective prevention and treatments remain unsatisfactory.
256 citations
,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.
253 citations
,
March 2006 in “The Journal of Clinical Endocrinology and Metabolism” This review discusses the hypothesis that polycystic ovary syndrome may originate in fetal life due to prenatal androgen exposure, but reports no new clinical results.
252 citations
,
February 2018 in “npj Regenerative Medicine” This review explores recent advances in understanding molecular mechanisms of tissue regeneration in mammals and suggests potential therapeutic targets, but it reports no new clinical results.
244 citations
,
September 2008 in “Annual Review of Genomics and Human Genetics” This review examines the direct-to-consumer genetic testing market, highlighting the available tests, regulatory issues, and calls for increased oversight, and reports no new results.
174 citations
,
November 2016 in “Cell stem cell” This study found that squamous cell carcinomas from hair follicle stem cells are more prone to epithelial to mesenchymal transition and metastasis than those from interfollicular epidermis, due to distinct chromatin landscapes.
159 citations
,
October 2015 in “Science Advances” This study observed that applying JAK-STAT pathway inhibitors to mouse and human skin led to rapid hair growth by inducing the anagen phase of hair follicles.
146 citations
,
June 2012 in “PLoS ONE” This study observed that quiescent label-retaining cells in the intestine, identified by Paneth cell markers, can switch to a proliferative state and activate Bmi1 expression during tissue injury, contributing to tissue regeneration.
138 citations
,
June 2012 in “Genes & Development” This study found that dermal Shh signaling regulates specific dermal papilla signatures essential for maintaining hair follicle development, suggesting that the Shh-Noggin signaling loop is crucial for hair morphogenesis.
137 citations
,
April 2015 in “Nature Reviews Molecular Cell Biology” This review discusses the distinct roles and surprising developmental flexibility of multiple somatic stem cell types in tissue maintenance and repair, reporting no new results but highlighting emerging questions about their regulation and origins.
130 citations
,
September 2018 in “Cell Reports” This study found that macrophages play a crucial role in nerve regeneration by regulating Schwann cell dynamics and remyelination, with Gas6 identified as a key factor in this process.
106 citations
,
September 2010 in “Stem cells” This study found that skin-derived precursor cells in mice can originate from both neural crest and somite lineages but show functional similarities regardless of their developmental origins.
88 citations
,
January 2019 in “Journal of Tissue Engineering and Regenerative Medicine” This review discusses current uses and advancements in mesenchymal stem cell-derived conditioned media as a potential regenerative therapy but does not present new clinical findings.
87 citations
,
January 2016 in “Development” This study suggests that the postnatal loss of hair follicle formation in wounds may be due to elevated Wnt/β-catenin activation in the dermis, affecting fibroblast function in mice.