research Role of Cholesterol Sulfate in Epidermal Structure and Function: Lessons from X-Linked Ichthyosis
Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.
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research Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis
The document concludes that diagnosing and treating Human African Trypanosomiasis is challenging, but new treatments like fexinidazole are promising.
research Are the Cutaneous Manifestations During or Due to SARS-CoV-2 Infection/COVID-19 Frequent or Not? Revision of Possible Pathophysiologic Mechanisms
Skin problems in COVID-19 patients are rare and may be due to the body's complex immune response or blood clotting issues.
research Foxp3 Post-Translational Modifications and Treg Suppressive Activity
Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.
research Inherited Ichthyoses: Generalized Mendelian Disorders of Cornification
Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.
research What Causes Hidradenitis Suppurativa?—15 Years After
Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.
research Skin Connective Tissue and Aging
Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.
research N-Terminal Functional Domain of Gasdermin A3 Regulates Mitochondrial Homeostasis via Mitochondrial Targeting
Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.
research Skin Aging
After menopause, women lose a lot of skin collagen, but estrogen replacement might improve skin health.
research Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition
Certain mice without specific receptors or mast cells don't lose hair from stress.
research Crafting Polymeric and Peptidic Hydrogels for Improved Wound Healing
Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.
research A Current Review of the Cutaneous Manifestations of Renal Disease
Skin problems are very common in people with end-stage kidney disease.
research Molecular Basis of Hair Cell Loss
The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.
research Toll-Like Receptor Function in Acute Wounds
Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.
research The Role of Macrophages in Skin Homeostasis
Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.
research The Role of Lymphocytes in the Development and Treatment of Alopecia Areata
Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.
research Apoptosis and Cutaneous Biology
Apoptosis is crucial for healthy skin and treating skin diseases.
research Pathogenesis of Cardiovascular Alterations in Dogs Treated with Minoxidil
Using minoxidil on dogs can cause serious cardiovascular damage, including arterial injury and hemorrhagic lesions.
research Wnt Signaling and Aging-Related Heart Disorders
Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.
research The Genetics of Hair Shaft Disorders
The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.
research Male Pattern Hair Loss: Current Understanding
Genetics and hormones cause hair loss; finasteride treats it safely.
research Pharmacological BACE1 and BACE2 Inhibition Induces Hair Depigmentation by Inhibiting PMEL17 Processing in Mice
Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.
research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells
High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.
research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate
The extracellular matrix is crucial for controlling skin stem cell behavior and health.
research Sequence-Structure Based Phylogeny of GPCR Class A Rhodopsin Receptors
The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.
research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes
Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.
research Age-Associated Inflammation Connects RAS-Induced Senescence to Stem Cell Dysfunction and Epidermal Malignancy
Older skin has higher cancer risk due to inflammation and stem cell issues.
research Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells
Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
research Engineering Pro-Regenerative Hydrogels for Scarless Wound Healing
Hydrogels could lead to better treatments for wound healing without scars.
research Effects of Dermatological Medications on Male Fertility
Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.