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Did you mean Benign Prostatic Hypertrophy?

GlossaryBenign Prostatic Hyperplasia

non-cancerous enlargement of the prostate gland common in older men

Benign Prostatic Hyperplasia (BPH), also known as an enlarged prostate, is a non-cancerous increase in the size of the prostate gland. This condition is common in older men and can lead to urinary symptoms such as difficulty starting urination, a weak urine stream, and frequent urination, especially at night. BPH occurs due to hormonal changes and can be managed with medications, lifestyle changes, or surgical procedures if necessary.

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Effect of Finasteride on Serum Concentrations of Dihydrotestosterone and Testosterone in Three Clinically Normal Sexually Intact Adult Male Dogs

research Effect of Finasteride on Serum Concentrations of Dihydrotestosterone and Testosterone in Three Clinically Normal Sexually Intact Adult Male Dogs

10 citations, June 1998 in “PubMed”

Finasteride significantly reduces DHT levels in male dogs without affecting testosterone levels, suggesting it could be used to treat benign prostatic hypertrophy in dogs weighing 10 to 50 kilograms.

research Androgen-Induced Norepinephrine Release in Male Accessory Sex Organ Smooth Muscle Growth and Differentiation

October 2019

Androgens increase norepinephrine release, promoting smooth muscle growth in male sex organs, which may contribute to benign prostatic hypertrophy.

research Disease Versus Disease: How One Disease May Ameliorate Another

21 citations, January 2006 in “Pediatrics”

Some diseases can improve the outcomes of other diseases, leading to new treatment possibilities.

research Role of 5α-Reductase in Health and Disease

101 citations, April 1994 in “Baillière's clinical endocrinology and metabolism”

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

research Persistent Sexual Side Effects of Finasteride: Could They Be Permanent?

112 citations, July 2012 in “The Journal of Sexual Medicine”

Finasteride may cause long-lasting sexual side effects.

research Biological Activity of Antiandrogens

51 citations, June 1970 in “British journal of dermatology/British journal of dermatology, Supplement”

Antiandrogens may help treat conditions like excessive hair growth, prostate tumors, male baldness, and acne by blocking male hormone effects.

research Oral Ivermectin in the Treatment of Scabies

30 citations, December 1999 in “International Journal of Dermatology”

Oral ivermectin effectively cured scabies with minimal side effects, and finasteride promoted hair growth in men with hair loss.

research History as a Tool in Identifying New Old Drugs

26 citations, January 2002 in “Advances in experimental medicine and biology”

Finasteride, originally for prostate issues, also treats hair loss, similar to effects from certain plants.

research A Regulatory Perspective on Pharmacokinetic/Pharmacodynamic Modelling

18 citations, June 1999 in “Statistical Methods in Medical Research”

The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.

research Endocrine Treatment of Benign Prostatic Hypertrophy: Current Concepts

11 citations, January 1991 in “Urology”

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

research Steady-State Pharmacokinetics of Oral Testosterone Undecanoate with Concomitant Inhibition of 5α-Reductase by Finasteride

10 citations, October 2010 in “International Journal of Andrology”

Finasteride doesn't affect oral testosterone undecanoate, and high DHT levels may cause acne, prostate issues, and hair loss.

research Effects of Long-Term Treatment With Finasteride (MK-906), a 5-Alpha Reductase Inhibitor, on Circulating LH, FSH, Prolactin, and Estradiol

10 citations, October 1992 in “Hormone and Metabolic Research”

Finasteride safely lowers DHT levels without affecting hormone levels, helping with conditions like enlarged prostate, acne, and hair loss.

research Finasteride Use During Pregnancy and Early Neonatal Outcome: A Case Report

3 citations, June 2018 in “International Journal of Clinical Pharmacy”

Baby born healthy despite mom taking finasteride, but more research needed.

research 5α-Reductase Inhibitors: The Finasteride Story

3 citations, November 2010 in “Wiley-VCH Verlag GmbH & Co. KGaA eBooks”

Finasteride safely treats enlarged prostate and male-pattern baldness.

research The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route

3 citations, October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

research Antiandrogenic Activity of Riboflavin 5′-Phosphate (FMN) in 22Rv1 and LNCaP Human Prostate Cancer Cell Lines

1 citations, January 2022 in “European Journal of Pharmacology”

Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.

research Sexual Dysfunction After 5-Alpha Reductase Inhibitor Use: Insights from the Reduce Study Group Database

April 2018 in “The Journal of Urology”

Dutasteride use can lead to a stable decline in sexual function that is not affected by age or prostate size.

research Screening of Steroid 5-Reductase Inhibitory Activity and Total Phenolic Content of Thai Plants

April 2011 in “Journal of Medicinal Plants Research”

Ocimum basilicum L. and red Oryza sativa L. may help with hair loss and prostate issues.

5α-Reductase Inhibitor Therapy: Should Physicians Be Concerned With Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients?

research 5α-Reductase Inhibitor Therapy: Should Physicians Be Concerned With Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients?

October 2010 in “Journal of Men's Health”

Some patients may experience lasting sexual dysfunction, depression, and other side effects from 5α-reductase inhibitor therapy.

research Total Prostate Volume as Risk Factor for Semen Pathologies in Aging Male

October 2010 in “Journal of Men's Health”

Larger prostate size in older men may be linked to poorer semen quality and fertility issues.

research Neuronal Mimicry as a Resistance Phenotype in Cancer Cells

March 2009 in “The Journal of Urology”

Low dose finasteride causes only small changes in PSA levels in older men with BPH.

Dutasteride/Finasteride: A Retrospective Study on Macular Abnormalities in Male Patients Treated for Benign Prostatic Hypertrophy or Alopecia

research Dutasteride/Finasteride: A Retrospective Study on Macular Abnormalities in Male Patients Treated for Benign Prostatic Hypertrophy or Alopecia

February 2021 in “Reactions Weekly”

Finasteride and dutasteride may cause macular abnormalities.

research Clinical Applications of Antiandrogens

29 citations, October 1988 in “Journal of Steroid Biochemistry”

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

research Health Issues Unique to the Aging Man

3 citations, September 2000 in “Geriatric nursing”

Aging men face unique health issues like erectile dysfunction, prostate problems, and baldness.

research Hormone Blocking Anticancer Drugs

March 2015

The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.

research Benign Prostatic Hyperplasia: A Disorder of Androgen Metabolism in Males

23 citations, May 1984 in “Journal of the American Geriatrics Society”

Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.

research 5α-Reductase Inhibitors and Prostatic Disease

21 citations, August 1994 in “Clinical endocrinology”

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.