research Finasteride
Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.
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research Role of 5α-Reductase in Health and Disease
5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.
research New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects
Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.
research Finasteride-Induced Gynecomastia
Finasteride can cause enlarged breasts.
research Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice
Dutasteride works better than finasteride for preventing and treating prostate cancer.
research Effects of In Utero Exposure to D-004, a Lipid Extract from Roystonea Regia Fruits, in the Male Rat: A Comparison with Finasteride
D-004 may be a natural alternative to finasteride for treating enlarged prostate and male baldness.
research 5α-Metabolism in Finasteride-Treated Subjects and Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency
Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.
research 5-Alpha Reductase Inhibitors and Risk of Male Breast Cancer: A Systematic Review and Meta-Analysis
Taking 5-alpha reductase inhibitors does not increase the risk of breast cancer in men.
research Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)
Birth control pills increase certain receptor activities in female gerbil prostate glands and can lead to prostate changes.
research The Effects of Oral 5-Alpha Reductase Inhibitors on Penile Intracavernosal Pressures and Penile Morphology in a Rat Model
Oral finasteride and dutasteride may negatively affect erectile function in rats.
research Effects of 5-Alpha Reductase Inhibitors
5-alpha reductase inhibitors can cause sexual, neurologic, endocrine, and cardiovascular side effects, but these are rare and usually stop after ending treatment.
research Acute Pancreatitis Following Finasteride Toxicity: A Rare Case Report
Finasteride overdose can cause acute pancreatitis.
research Longitudinal Clinical Course in Patients With 5α-Reductase Type 2 Deficiency Treated With Testosterone and Dihydrotestosterone During Infancy and Puberty
Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.
research Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition
The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.
research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders
S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
research Effects of 5-Alpha Reductase Inhibitors on Erectile Function, Sexual Desire, and Ejaculation
5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.
research Prostate Cancer Incidence Among Finasteride and Alpha-Blocker Users in the Finnish Prostate Cancer Screening Trial
Finasteride might lower the risk of low-grade prostate cancer but not high-grade cancer, while alpha-blockers might reduce high-grade cancer risk.
research Selective Non-Steroidal Inhibitors of 5α-Reductase Type 1
Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.
research Clinical Application of 5α-Reductase Inhibitors
5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.
research A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors
The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.
research Meta-Analysis of Randomized Clinical Trials of Finasteride
Finasteride effectively treats BPH and hair loss but may cause sexual side effects.
research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors
New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.
research Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases
New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
research Clinical Use of 5α-Reductase Inhibitors
Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
research Post-Finasteride Syndrome: A Review of Current Literature
Post-finasteride Syndrome causes lasting negative effects, but more research is needed for treatment and risk evaluation.
research Persistent Gynecomastia Due to Short-Term Low-Dose Finasteride for Androgenetic Alopecia
A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.
research Pharmacokinetic Interaction Between Finasteride and Terazosin, but Not Finasteride and Doxazosin
Finasteride interacts with terazosin, but not doxazosin; caution needed.
research Finasteride-Induced Gynecomastia in a 62-Year-Old Man
Finasteride caused enlarged breast tissue in a 62-year-old man.
research Analyzing Finasteride Data
Finasteride slightly improves prostate symptoms but has minimal difference from placebo.
research Post-Finasteride Syndrome: An Emerging Clinical Problem
Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.