research Notch Signaling Is Significantly Suppressed in Basal Cell Carcinomas and Activation Induces Basal Cell Carcinoma Cell Apoptosis
Activating Notch signaling can kill basal cell carcinoma cells.
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research Understanding Cancer Cells of Origin in Cutaneous Tumors
The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.
research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in Mice
Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.
research The Rotterdam Study: 2018 Update on Objectives, Design, and Main Results
The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.
research The Efficacy of Dihydrotestosterone Transdermal Gel Before Primary Hypospadias Surgery: A Prospective, Controlled, Randomized Study
Dihydrotestosterone gel before hypospadias surgery led to less scarring but raised concerns about potential psychological effects and skin changes.
research Patched-Associated Tumors: Modifier Genes and Pathogenesis
The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.
research Actinic Keratosis: A Clinical and Epidemiological Review
Actinic keratosis can lead to skin cancer, is more common in fair-skinned people, and can be reduced with sunscreen and treated effectively.
research Physicochemical Characterization of Chitosan-Decorated Finasteride Solid Lipid Nanoparticles for Skin Drug Delivery
Chitosan-decorated nanoparticles can improve skin delivery and reduce side effects of finasteride.
research Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia
Medicines for enlarged prostate may raise the risk of breast growth and tenderness but not breast cancer.
research Liposomes with an Ethanol Fraction as an Application for Drug Delivery
Ethosomes improve drug delivery through the skin but may have side effects like irritation.
research Male Pattern Baldness and Risk of Incident Skin Cancer in a Cohort of Men
Men with male pattern baldness have a higher risk of certain skin cancers, especially on the scalp.
research A Case of Squamous Cell Carcinoma of the Scalp After Several Synthetic Hair Grafts
A man developed skin cancer on his scalp after multiple artificial hair grafts.
research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse
Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.
research Cutaneous Toxicities of New Treatments for Melanoma
New melanoma treatments can cause skin side effects, including skin cancer and rashes, but combining treatments may reduce these risks.
research Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.
research Targeting Smoothened for Therapeutic Gain
Targeting the Smoothened receptor shows promise for treating certain cancers.
research Epidemiology of Skin Cancer in the Mature Patient
Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.
research Long-Term Use of 5α-Reductase Inhibitors and the Risk of Male Breast Cancer
Taking 5α-reductase inhibitors does not significantly increase the risk of breast cancer in men.
research Trapa Bispinosa Roxb. Pericarp Extract Exerts 5α-Reductase Inhibitory Activity in Castrated Benign Prostatic Hyperplasia Model Mice
Trapa bispinosa Roxb. extract may help reduce prostate size and cell growth in BPH.
research Characterization of CD4+ Stem Cells of the Skin and Their Role in Skin Homeostasis and Tumorigenesis
CD4+ skin cells may be precursors to basal cell carcinoma.
research Docetaxel-Induced Psoriasis: A Case Report
Docetaxel, a chemotherapy drug, was reported to cause psoriasis in a patient for the first time.
research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice
Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.
research Homologous Recombination Induced by Doxazosin Mesylate and Saw Palmetto in the Drosophila Wing-Spot Test
Doxazosin mesylate and saw palmetto cause genetic changes in fruit flies.
research Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road
New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.
research Effect of Finasteride on Prostate-Specific Antigen
Finasteride significantly reduces PSA levels in men, and doctors should adjust PSA readings for those taking the drug.
research A Herbal Formula, Comprising Panax Ginseng and Bee-Pollen, Inhibits Development of Testosterone-Induced Benign Prostatic Hyperplasia in Male Wistar Rats
A mix of Panax ginseng and bee-pollen may help prevent prostate enlargement in rats.
research Finasteride Use and Risk of Male Breast Cancer: A Case-Control Study Using Individual-Level Registry Data from Denmark, Finland, and Sweden
Finasteride use is not clearly linked to an increased risk of male breast cancer.
research Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents
Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.
research Metastatic Embryonal Cell Carcinoma with High Testosterone and Absence of Secondary Sexual Characteristics
Treatment restored normal sexual characteristics and blood condition in a patient with testicular cancer.
research Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors
Inactive hair follicle stem cells help prevent skin cancer.