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Lack of sleep in mice leads to prostatitis by reducing certain hormones and activating an inflammatory pathway, which can be temporarily fixed with normal sleep.

Family doctors can manage older men with urinary symptoms using exams, tests, and medications.

Finasteride reduces blood loss and the need for blood transfusions during and after TURP surgery.

Doxazosin mesylate and saw palmetto cause genetic changes in fruit flies.

New treatments targeting fibrosis could improve urinary symptoms in BPH.

5-alpha reductase inhibitors can cause sexual, neurologic, endocrine, and cardiovascular side effects, but these are rare and usually stop after ending treatment.

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Finasteride safely lowers DHT levels without affecting testosterone.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

Finasteride-loaded nanoparticles may help treat alopecia.

Lovastatin doesn't improve lower urinary tract symptoms treatment.

Cyclodextrins improve finasteride's solubility and bioavailability for hair loss treatment.

Metabolic syndrome linked to urinary symptoms; hair loss not significant.

5α-reductase inhibitors may worsen sexual drive and spontaneous erections but don't worsen existing erectile or ejaculatory problems.

Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.

Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.

Finasteride interacts with terazosin, but not doxazosin; caution needed.

Method accurately measures finasteride and tamsulosin in combined drug form.

5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.

Two methods can measure finasteride and tamsulosin hydrochloride; HPLC is more advantageous, while TLC offers better separation.

Combination therapy for 9+ months maintains symptom improvements after stopping alpha-blockers or finasteride.

The method measures finasteride accurately and cheaply using UV light.

Researchers developed a quick and accurate method to measure finasteride and tamsulosin in tablets.

Post-finasteride Syndrome causes lasting negative effects, but more research is needed for treatment and risk evaluation.

Finasteride helps hair growth.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Optimized film improves finasteride skin absorption and treatment efficiency.