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This study found that FLCN deficiency in mice muscles led to increased mitochondrial biogenesis and a metabolic shift towards oxidative phosphorylation, with a similar advantage observed in FLCN-null kidney cancer cells.

This review discusses the drug repurposing of cardiovascular medications like aspirin and statins for new uses, including potential anti-tumor effects, noting promising experimental outcomes but less conclusive clinical trials, particularly in the field of cancer treatment.

This review discusses the potential role of steroid 5α-reductase inhibitors in treating neuropsychiatric disorders related to dopaminergic hyperreactivity but reports no new clinical results.

This review discusses newly identified non-Edg family lysophosphatidic acid receptors, detailing their roles in vascular development, platelet activation, and hair growth, and reports no clinical results.

This review discusses phytotherapy options for managing benign prostatic hyperplasia, noting some herbal agents show promise in trials for mild-moderate symptoms but more evidence is needed for others.

This study explored the complex roles of niche cells in regulating hair follicle stem cells, identifying specific cell functions such as signaling, sensing, and relaying messages, which could provide insights into treating hair loss conditions like androgenetic alopecia and alopecia areata.

This review discusses recent data on the use of anabolic-androgenic steroids and other steroid compounds and reports no new clinical results.

This review discusses the nutrient profile and potential health benefits of pumpkin and watermelon seeds, concluding they are underutilized and could be developed into various nutraceuticals.

This review discusses the enhanced understanding of how stem cell niches respond adaptively to systemic signals, aging, and local perturbations, but reports no new research findings.

This review explores genetic and lifestyle factors influencing hair diversity and reports no new findings, calling attention to the potential for future discoveries in genetic and epigenetic research.

This article reviews the hormonal pathogenesis and treatment strategies for acne vulgaris, particularly in women with severe or treatment-resistant cases, associating it with hormonal imbalances and hyperandrogenism.

This review discusses the role of δ-subunit-containing GABA A receptors and neurosteroids in temporal lobe epilepsy, highlighting their plasticity and potential pharmacological implications, without reporting new clinical results.

This review discusses the cardiovascular risks associated with anabolic-androgenic steroid use and reports that, despite known toxic effects, further research is needed to clarify the causality of these risks.

This study found that in Japanese male patients with androgenetic alopecia, dutasteride 0.5 mg daily over 52 weeks was associated with improvements in hair growth and appearance, with reported adverse events mostly mild.

This study found that both finasteride and dutasteride act as slow, time-dependent inhibitors of steroid 5α-reductase type II, with dutasteride being more efficient, influenced by the enzyme's genetic variants.

In this animal study, soy isoflavones were found to protect lung tissue from the adverse effects of radiation, such as skin injury, inflammation, and fibrosis, suggesting a potential radioprotective benefit.

This review examines patents and publications on steroid sulfatase inhibitors since 1999 and reports no new clinical results, highlighting their potential for treating estrogen- and androgen-driven conditions.

This study found that a composition including Serenoa repens extract and anti-inflammatory agents effectively suppressed inflammation-related gene expression in a keratinocyte model, suggesting a potential dual strategy for treating androgenetic alopecia.

This review discusses the role of steroid sulfatase in steroid hormone metabolism and highlights the need for more research on its expression and regulation, especially regarding hormone-dependent tumors.

The researchers suggest that testosterone levels might influence COVID-19 susceptibility and severity, with low levels potentially protecting against infection but possibly worsening severe disease due to cytokine storm activation.

This review discusses cross-sex hormone therapy for managing gender dysphoria in transsexual individuals and reports no new clinical results; it highlights the need for education and culturally sensitive training for healthcare professionals.

This study reports that male-pattern baldness may be linked to an increased risk of skin cancer, particularly for tumors located on the scalp.

In this study, researchers found that hair follicle-derived mesenchymal stem cells, modified to overexpress extracellular matrix protein 1, significantly improved liver function and reduced liver damage in cirrhotic mice by inhibiting hepatic stellate cell activation and TGF-β/Smad signaling.

This study found that prostaglandin D2 promotes androgen receptor and AKT signaling in human dermal papilla cells through the DP2 receptor, potentially contributing to androgenetic alopecia.

This review discusses the adverse skin effects of EGFR inhibitors used in cancer treatment, exploring their mechanisms and offering strategies for prevention and management, but reports no new experimental findings.

This study found that chronic exposure to finasteride did not significantly impact spermatogenesis in rats.

This article discusses diagnostic and treatment options for excessive hair growth in women, noting a need for holistic approaches to address associated psychological issues, but it does not present new clinical findings.

This review discusses various factors influencing hair growth, including alopecia and hirsutism, and highlights recent advancements in treatment approaches without reporting new clinical results.

This source outlines what it takes to be a competent provider for transgender individuals, focusing on their health needs, disparities, and coverage, and examines medical biases and hormone treatment guidelines, alongside treatment options for different age groups, concluding with evolving trends in medical education.

This study suggests that genetic variants in the androgen receptor gene may predict which postmenopausal women with hair loss respond to finasteride therapy.