11 citations
,
January 1991 in “Urology” This article reviews the potential of combining antiandrogenic and antiestrogenic treatments for BPH, highlighting aromatase inhibitors, but presents no new clinical results; further research is needed.
7 citations
,
February 2019 in “Journal of pharmacological sciences” This study found that Bazhengsan significantly reduced inflammation and hyperplasia in male rats with nonbacterial prostatitis, indicating potential as a treatment for chronic prostatitis.
4 citations
,
October 2013 in “Springer eBooks” This chapter reviews existing knowledge about melatonin's MT₁ and MT₂ receptors in human tissues, discussing their established and potential functions, but reports no new clinical findings.
2 citations
,
January 2025 in “Pharmaceutical Research” This article reviews the possible therapeutic activities of Angelica gigas Nakai root extracts and their components, noting their potential effects on neuro-cognitive, metabolic, and other health conditions, and reports no new clinical results.
1 citations
,
June 2008 in “The Journal of Urology” This letter to the editor references a study on using dihydrotestosterone gel before hypospadias surgery but itself contains no new findings.
This study found that combining finasteride and anastrozole was more effective in preventing and treating benign prostatic hyperplasia in rats than using either drug alone.
December 2005 in “Current Prostate Reports” This review discusses the historical and current use of androgen manipulation for treating benign prostatic hyperplasia and reports no new clinical results.
March 2023 in “Translational Andrology and Urology” This review discusses the pharmacology of 5-alpha reductase inhibitors, their expanding clinical indications beyond benign prostatic hyperplasia, and notes unresolved claims about their potential role in SARS-CoV-2.
27 citations
,
February 2023 in “Frontiers in Cell and Developmental Biology” This review discusses the expanded understanding of WNT10B's role in various tissues and diseases over the past decade, emphasizing its genetic correlations and potential therapeutic implications, but reports no new clinical results.
4 citations
,
September 2006 in “European Urology Supplements” Dutasteride reduces DHT and improves BPH symptoms more effectively than finasteride.
January 2003 in “Humana Press eBooks” This review discusses the roles of dihydrotestosterone in fetal development and adult diseases, reporting no new clinical results; the authors emphasize the potential of 5α-reductase inhibitors for treatment.
43 citations
,
January 2006 in “PubMed” This article summarizes findings on the role of androgens and estrogens in male reproductive tissues across species, highlighting the roles of hormone metabolism, receptor distribution, and stress-induced changes.
3 citations
,
December 2021 in “Recent patents on anti-cancer drug discovery” This review examines the role of SET7/9 in non-histone methylation and its implications in various diseases, including cancer, but presents no new clinical results.
March 2024 in “Cell communication and signaling” This study found that sleep deprivation in mice can trigger prostatitis by activating the cGAS-STING pathway due to reduced levels of dihydrotestosterone and melatonin, resulting in a pro-inflammatory environment, while recovery sleep can mitigate these effects.
This review examines natural bioactive compounds for their potential to alleviate androgenetic alopecia, emphasizing compounds like ginseng and curcumin, but reports no new experimental results.
49 citations
,
November 2021 in “Annual review of pathology” This review discusses the regulatory roles of lysophospholipids like LPA and S1P in diseases such as fibrosis, neuropathic pain, and cancer, but reports no new clinical results.
22 citations
,
August 2020 in “Cells” This review discusses the role of TGM3 in skin and hair follicle biology, human tumor pathology, and genetic abnormalities, and reports no novel results; the authors highlight its potential as a cancer diagnostic biomarker.
13 citations
,
April 2019 in “International journal of molecular sciences” This article reviews the potential of Acyzol, a zinc-containing drug, to treat and prevent zinc deficiency conditions, but it reports no new clinical findings.
10 citations
,
July 2022 in “Journal of Medicinal Chemistry” This article discusses the potential for combining PROTACs with other therapeutic modalities in drug discovery and reports no clinical results.
149 citations
,
January 2011 in “Nature reviews. Urology” Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.
12 citations
,
December 2015 in “F1000Research” This article discusses advancements and future directions in the treatment of benign prostatic hyperplasia, highlighting ongoing clinical trials of novel techniques, but it reports no new clinical results.
9 citations
,
August 2024 in “Pharmacological Reviews” This review summarized advancements in intestinal lymphatic drug delivery, emphasizing the evolving understanding of lymphatics as active players in health and disease, which has led to innovative therapeutic strategies and enhanced pharmacokinetic outcomes via this delivery route.
3 citations
,
November 2024 in “Egyptian Journal of Medical Human Genetics” This bibliometric analysis identified SGK1 as a key factor in cancer, showing that its dysregulation can lead to tumor growth and treatment resistance. The authors highlighted SGK1's potential as a therapeutic target, but note that further research is needed to develop effective treatment strategies.
January 2023 in “WikiJournal of Medicine” This review discusses alternative androgen pathways, including the "backdoor" pathway and pathways to 11-oxygenated steroids, and reports no new clinical results; the authors aim to clarify these concepts for better patient treatment.
January 2012 in “Курский научно-практический вестник "Человек и его здоровье"” In this study, indications for monotherapy with 5-alpha-reductase inhibitors, such as finasteride and herbal drugs, were developed based on clinical and morphological changes in patients with benign prostatic hyperplasia.
21 citations
,
January 2023 in “International Journal of Molecular Sciences” This review discusses the role and interactions of the calcium-binding protein S100A6 in cellular processes and its association with various diseases, highlighting the need for further research to fully understand its biological impact.
10 citations
,
August 2023 in “Advanced Science” This review discusses nitric oxide's physiological roles and the development of strategies for delivering it exogenously, without presenting new clinical results.
5 citations
,
April 2024 in “ACS Chemical Neuroscience” This study developed and validated a highly sensitive method using ultrahigh-performance liquid chromatography with tandem mass spectrometry for accurately analyzing nine neuroactive steroids in human serum, which could enhance understanding of disease pathophysiology and support new biomarker and therapeutic discovery.
1 citations
,
October 2009 in “Cancer Epidemiology Biomarkers & Prevention” This review discusses the American Society of Preventive Oncology's focus on cancer prevention and highlights the ongoing challenges and developments in screening, tobacco control, and the need for innovative risk-reduction strategies; it reports no new research findings.
April 2026 in “Future Medicinal Chemistry” This article discusses the impact of PROTACs technology in transforming drug discovery with its novel degradation mechanism, but it reports no new experimental findings.