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Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

Oxidative stress affects hair loss in men with androgenetic alopecia.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Female Pattern Hair Loss affects women's self-esteem and needs more research for better treatment.

Prolactin affects hair growth cycles and can cause early hair follicle regression.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

Minoxidil and finasteride effectively treat hair loss.

Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

New methods improve how we test hair growth treatments, but challenges like slow hair changes and high costs remain.

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

Phospholipase A2 is necessary for the correct placement of PIN proteins in plant roots, affecting root growth.

Sponge helps heal wounds faster with less inflammation and better skin/hair growth.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.