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30-60 / 1000+ resultsresearch Protective effect of a novel metal-phenolic network composite against ultraviolet-induced skin damage by modulating MAPK/AP-1/NF-κB signaling pathways and attenuating oxidative stress in human keratinocytes
This study found that Melamax®, originally developed as an eco-friendly hair dye, provides significant protection against ultraviolet-induced oxidative and inflammatory damage in keratinocytes by modulating gene expression and signaling pathways, highlighting its dual potential for cosmetic coloration and skin photoprotection.
research Pitfalls of PCR-Based Strategy for Genotyping Cre-Loxp Mice
This study observed that PCR-based genotyping for cre-loxP mice can lead to errors due to cre-mediated recombination in non-target tissues like tails, affecting the detection of lox alleles.
research Computational design and development of a novel voltammetric sensor for minoxidil detection based on electropolymerized molecularly imprinted polymer
In this study, a novel electrochemical sensor using a molecularly imprinted polymer was developed for the sensitive detection of minoxidil, successfully measuring its concentration in real samples.
research Evaluation of Phytochemicals and Anticancer Potential of C. maxima: An In-silico Molecular Docking Approach
This study found that compounds extracted from Cucurbita maxima seeds at 50 °C for 2 hours demonstrated significant binding affinities against breast cancer-related proteins, suggesting potential anticancer activity needing further in vitro and in vivo evaluation.
research BroadAMP-GPT: AI-Driven generation of broad-spectrum antimicrobial peptides for combating multidrug-resistant ESKAPE pathogens
This study developed BroadAMP-GPT, a computational-experimental framework, to discover new antimicrobial peptides, identifying candidates effective against multidrug-resistant pathogens. Notably, AMP_S13 showed strong stability, low toxicity, and efficacy in infection models, highlighting the platform's potential in combating antimicrobial resistance.
research Voltammetric sensing of minoxidil using a molecularly imprinted polymer (MIP)-modified carbon paste electrode
This study developed and optimized a molecularly imprinted polymer-based electrochemical sensor, demonstrating its ability to detect minoxidil with high sensitivity and selectivity at concentrations as low as 0.3 nM, and successfully applied it for minoxidil measurement in various real sample matrices.
research MULTIOMICS – A NEW EXCITING ERA OF RESEARCH
In this study, researchers at the Laboratory of Regenerative Medicine WUM are exploring the long-term effects of SARS-CoV-19 infection, focusing on stem cell mobilization and engraftment processes, and utilizing advanced diagnostic techniques to develop algorithms for rare disease classification, including amyloidosis.
research Generation of Pax1/PAX1-Specific Monoclonal Antibodies
This study developed rat monoclonal antibodies that specifically detect Pax1/PAX1 protein, which could improve diagnostic protocols for conditions involving deregulated Pax1/PAX1 expression.
research Genetic Fate Mapping Using Site-Specific Recombinases
This review discusses five genetic fate mapping methods used to study cell behaviors during development and regeneration, detailing the necessary tools and considerations without reporting new experimental results.
research Fidelity of the Human Mitochondrial DNA Polymerase
This research quantified the fidelity of human mitochondrial DNA polymerase and found it averages 1 error in 440,000 nucleotides, impacting its function related to disease and mitochondrial health.
research Determination of Minoxidil by Bleaching the Permanganate Carrier Solution in a Flow-Based Spectrophotometric System
This study demonstrated that a flow injection method using potassium permanganate for detecting minoxidil provided accurate recoveries and agreed closely with HPLC results, showing potential for effective analysis of commercial samples.
research Optimal processing for proteomic genotyping of single human hairs
This study found that optimizing proteomic genotyping conditions from single human hair samples significantly improves the detection of genetically variant peptides, enhancing human identification with high precision across different biogeographic backgrounds.
research Etudes des perturbations par les éoliennes des équipements électromagnétiques de localisation maritimes et fluviaux
This protocol paper details methods for live imaging and analysis of dividing germline stem cells in C. elegans and reports no new research findings.
research A method for the determination of minoxidil in hair-regrowth formulations by micellar electrokinetic capillary chromatography
This study developed a micellar electrokinetic capillary chromatography method for determining minoxidil in Rogaine and generic products, offering a simple and efficient alternative to HPLC.
research Mitogen‐regulated protein/proliferin mRNA induction following single applications of tumor promoters to murine skin
This study found that mrp/plf-mRNA expression in murine skin increases in response to different tumor promoters, suggesting its potential as a short-term biomarker for chemical carcinogenesis.
research QuantAnts machines discover biomarkers for RAS signaling activation and design sgRNAs for CRISPR to target complex CD9, CD34, and CD74.
In this study, the researchers developed a quantum algorithm, QuantAnts machines, which identified complexes of CD9, CD34, and CD74 as potential targets for certain cancers involving the RAS pathway.
research Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model
This study found that proton minibeam radiotherapy demonstrated a potential tissue-sparing effect in epidermis models by spatially confining DNA damage, suggesting reduced side effects in radiotherapy.
research Quantitation of human mitochondrial DNA and whole mtGenomes sequencing of fingernail/hair shaft samples
In this study, researchers found that massively parallel sequencing of mitochondrial DNA (mtDNA) can improve information recovery from forensic samples, with successful full region amplification possible from as few as 2,000 mtDNA copies, albeit with variability in heteroplasmy among hair samples from the same donor.
research MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway
This study found that overexpression of miR-214 in keratinocytes inhibits hair follicle development and cycling by targeting β-catenin in the Wnt signaling pathway.
research Ultrahigh-Power Sonicator Lysis Enables Deep Proteomic Profiling of Hair Shafts for Fetal Growth Restriction Biomarker Discovery
This study developed an ultrahigh-power sonicator to improve protein extraction from hair shafts, followed by advanced proteomic analysis, identifying 239 differentially expressed proteins in fetal growth restriction cases compared to healthy controls, which were validated as potential biomarkers for perinatal diagnostics.
research Ultrahigh-Power Sonicator Lysis Enables Deep ProteomicProfiling of Hair Shafts for Fetal Growth Restriction Biomarker Discovery
This study developed a new method using ultrahigh-power sonication and mass spectrometry to improve protein extraction from hair shafts, identifying 239 differentially expressed proteins related to fetal growth restriction, which were validated as potential noninvasive biomarkers for perinatal diagnostics.
research Label-Free Monitoring of Endometrial Cancer Progression Using Multiphoton Microscopy
This study found that multiphoton microscopy imaging allows for detailed observation and quantitative analysis of collagen alterations in the progression of endometrial cancer, potentially offering a faster, more accurate method for early diagnosis compared to current protocols.
research Cross-species amplification of human microsatellite markers in pig-tailed and stump-tailed macaques
Some human genetic markers work for genetic studies in pig-tailed and stump-tailed macaques, which can help in their conservation.
research Wavelength-encoded laser particles for massively-multiplexed cell tagging
This study introduced laser particles as a new imaging probe capable of real-time tracking of thousands of individual cells in 3D tumor models, suggesting potential for advanced single-cell analyses.
research Abstracts
Among families with pediatric brain disease, this study identified over 200 novel genetic causes, revealing potential treatment points using drug repurposing or nutritional supplementation.
research Properties and use of plant stem cells in cosmetic products
This article discusses the role and potential of plant stem cell extracts in cosmetics for their antioxidant and protective effects on skin cells, reporting no new clinical results; the authors highlight ecological and sustainable production methods.
research Changes in the level of sex hormones with aging and their influence on the voice
This review evaluates current research on how hormonal changes due to aging impact voice quality, concluding the vocal cords are sensitive to hormonal fluctuations throughout life but reports no new clinical results.
research Preclinical Challenges in Proton Minibeam Radiotherapy: Physics and Biomedical Aspects
This review discusses the experimental strategies and technological challenges of proton minibeam radiotherapy (pMBRT) and reports no clinical results; it highlights the potential of using a 3 GHz linear accelerator for precision therapy research.
research Development and validation of a procedure for the determination of minoxidil in hair-regrowth formulations using two variants of capillary zone electrophoresis
This study developed a high performance capillary electrophoresis method, validated for both legal and illicit minoxidil-based products, to confirm minoxidil's presence alongside known impurities.