11 citations
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March 2013 in “Journal of Applied Biomedicine” This study found that β-catenin is essential for hair follicle stem cell proliferation and may regulate this process through the PI3K/Akt pathway, suggesting its potential as a therapeutic target.
10 citations
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May 2016 in “Journal of Dermatological Science” This study found that PDGF-BB affects human melanocytes differently depending on their differentiation stage, stimulating melanoblast proliferation but inhibiting melanocyte proliferation while promoting their differentiation.
9 citations
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August 2018 in “Biomedical dermatology” This study found that topical administration of the TGFβ mimetic peptide DPS-1 stimulated hair growth in mice by promoting HDP cell proliferation and enhancing hair follicle morphology.
8 citations
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March 2019 in “Journal of Biomedical Materials Research Part A” This laboratory study found that collagen matrices with high-sulfated hyaluronan may enhance the cultivation of human keratinocytes and melanocytes from hair follicles for epidermal graft development.
8 citations
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January 2013 in “Australasian journal of dermatology” This review examines trichodysplasia spinulosa, a rare virus-linked skin condition in immunosuppressed individuals, noting its clinical features and highlighting antiviral treatment efficacy, without new clinical results.
8 citations
,
January 2001 in “Methods in enzymology on CD-ROM/Methods in enzymology” This article discusses methods to evaluate hair growth stimulants and reports no new clinical results; the authors highlight the need for more precise identification of stem cell sites in hair follicles.
7 citations
,
September 2020 in “Frontiers in Cell and Developmental Biology” This study found that recombinant murine IL-36α increased the number of regenerated hair follicles and accelerated wound healing in a mouse model of wound-induced hair follicle neogenesis.
6 citations
,
February 2023 in “Genes” This study found that overexpression of the CUX1 protein promotes proliferation of Hu sheep dermal papilla cells and affects key genes in the Wnt/β-catenin signaling pathway.
6 citations
,
July 2013 in “Molecular Imaging” This study successfully used noninvasive bioluminescence imaging to monitor hair generation in vivo after transplanting hair follicle stem cells in mice.
4 citations
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May 2025 in “Cells” This study found that miR-370-3p targets SMAD4 to inhibit cell proliferation, promote apoptosis, and affect the cell cycle in follicular papilla cells, demonstrating differences in their expression in sheep tissues, which may impact hair follicle development.
4 citations
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April 2024 in “Cellular and Molecular Biology” In this study, injectable platelet-rich fibrin (i-PRF) was found to enhance the proliferative, migratory, and hair-inducing abilities of dermal papilla cells more effectively than platelet-rich plasma through the TGF-β/Smad pathway.
4 citations
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May 2019 in “Zeitschrift für Naturforschung C” This study found that Ishige sinicola extract stimulated osteoblast differentiation and bone formation in MC3T3-E1 cells, suggesting potential use for osteoporosis prevention and treatment.
4 citations
,
January 2014 in “Repositorio Institucional” This study found that Clitocybin A from Clitocybe aurantiaca mushrooms may promote hair growth by enhancing cell-cycle progression and activating signaling pathways in dermal papilla cells.
3 citations
,
September 2021 in “Journal of Clinical Medicine” In this study, fingertip regeneration in mice was associated with specific signaling pathways involving hair follicles and hedgehog signaling, with potential implications for improving human hand injury treatments.
3 citations
,
March 2013 in “PubMed” This study found that applying 10% platelet-rich plasma significantly increased hair follicle density and reduced the time for hair formation in a mouse model compared to no PRP treatment.
3 citations
,
January 2005 in “Biological & Pharmaceutical Bulletin” This study reports that the peptide GPIGS, found in Bacillus sp. M18 conditioned medium, may promote hair growth through the PI-3K/Akt pathway and accelerate hair regrowth in mice.
2 citations
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August 2023 in “Journal of Endocrinological Investigation” In this study, researchers found that pregnant mice exposed to excessive androgen led to thinner ventricular walls and cardiac hypertrophy in offspring, suggesting that prenatal androgen exposure adversely affects cardiac health through reduced cardiomyocyte proliferation.
2 citations
,
August 2023 in “Ecotoxicology and environmental safety” This study found that vitamin A significantly enhanced the proliferation and inhibited apoptosis of rabbit dermal papilla cells under heat stress, likely by modulating miR-195/IGF1 and Wnt10b/β-catenin signaling pathways.
2 citations
,
March 2013 in “Phytotherapy Research” This study found that ascorbigen increased growth of dermal papilla cells but did not significantly protect against chemotherapy-induced alopecia in a mouse model, suggesting limited effectiveness for hair regrowth in this context.
1 citations
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July 2024 in “International Journal of Molecular Sciences” In this study, miR-181a was found to inhibit the proliferation and induction abilities of ovine dermal papilla cells by targeting the GNAI2 gene and affecting the Wnt/β-Catenin signaling pathway, highlighting its role in the regulation of hair follicle growth and development.
1 citations
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January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that injury-induced proliferation of wild-type cells can suppress oncogenic growth in Ras-mosaic skin.
This study found that extracellular matrix components influenced the adhesion and proliferation of stem cells from various sources differently, with only laminin reducing proliferation in certain mesenchymal stem cells.
August 2026 in “Non-coding RNA Research” The study reports that vitamin E improves hair-follicle growth and dermal papilla cell proliferation in vitro by modulating the lncRNA2919/STAT1/SHH axis in Angora rabbits, enhancing cellular antioxidant capacity.
July 2026 in “Journal of Craniofacial Surgery” This study found that silencing SRD5A2 and applying melatonin significantly boosted proliferation and migration of human hair follicle stem cells without causing differentiation, while increasing MT1 expression and reducing 5-alpha-reductase levels.
March 2026 in “Frontiers in Veterinary Science” This study found that all-trans retinoic acid (ATRA) inhibits proliferation and promotes apoptosis in secondary hair follicle-derived dermal papilla cells from cashmere goats, likely via the TGF-β2/Smad2/3 signaling pathway.
September 2025 in “Frontiers in Medicine” This study found that angiopoietin-1 significantly reduces apoptosis and promotes proliferation in human follicle dermal papilla cells under DHT-induced stress, suggesting its potential as a therapeutic candidate for androgenetic alopecia.
This study found that the long non-coding RNA lnc056 promotes the proliferation of hair follicle stem cells by upregulating TRIP6 expression through interaction with the transcription factor HNRNPUL1, suggesting a potential target for hair loss treatment.
May 2025 in “BMC Genomics” This study found that circ 0020938 suppresses hair follicle stem cell proliferation by interacting with the miR-142-5p/DSG4 axis, which aids in the hair follicle cycle's proper progression.
In this study, human hair dermal papilla cells were incubated with varying concentrations of umbilical cord-derived mesenchymal stem cell exosomes or minoxidil, and cell proliferation was assessed, showing significant results compared to the control.
March 2025 in “Molecules” This study found that Kyoh®, a flavonol-rich extract from rocket leaves, may promote hair growth by enhancing the expression of hair growth-related genes in laboratory conditions.