37 citations
,
October 2009 in “Veterinary Dermatology” This study identified and isolated highly proliferative canine keratinocytes in vitro, finding that follicular keratinocytes showed distinct proliferative capacity and marker expression indicative of putative epithelial stem cells.
23 citations
,
June 2015 in “Journal of Tissue Engineering and Regenerative Medicine” This study demonstrated that a 3D air–liquid culture system using Wnt-CM-treated cells can induce hair regeneration in nude mice and may facilitate large-scale preparation for hair loss treatment.
July 2022 in “Skin research and technology” This report describes common skin CT features of rosacea identified using a reflective confocal microscope, facilitating more objective diagnosis but highlights the need for further clinical exploration.
36 citations
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April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that canine bulge-derived keratinocytes are highly proliferative and can reconstitute pilosebaceous structures, indicating their potential utility in studying human stem cell biology and hair disorders.
November 2022 in “Journal of Investigative Dermatology” This study found that short-term treatment with ROCKi significantly increased keratinocyte stem cell proliferation without affecting their stemness, suggesting a potential safe approach for improving in vitro keratinocyte cultures for clinical applications.
1 citations
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January 2016 in “Methods in molecular biology” This article reviews a new method to accurately estimate proliferative and migratory epithelial cell numbers post-wounding but reports no experimental findings; the authors suggest its relevance to skin stem-cell biology research.
May 2024 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft” This case study describes a middle-aged woman diagnosed with a proliferating trichilemmal tumor on her scalp, emphasizing the importance of comprehensive diagnostic approaches and highlighting surgical excision as the primary treatment.
August 2020 in “Research Square (Research Square)” This study found that physoxia improved hair follicle functions in co-cultures of dermal papilla cells and melanocytes by enhancing their biological activities and promoting hair growth and pigmentation.
16 citations
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May 2017 in “Journal of Clinical Ultrasound” This report describes the sonographic characteristics of a proliferating trichilemmal tumor in the subungual region, identifying it as a heterogeneous mass with echogenic foci, potentially representing keratin and cholesterol.
9 citations
,
March 2018 in “Journal of the Formosan Medical Association” In this study, chitosan membranes enhanced melanocyte proliferation and survival by supporting both cell-cell and cell-substrate interactions, unlike polyvinyl alcohol membranes which only facilitated cell-cell interactions.
2 citations
,
June 2001 in “Medical Electron Microscopy” This study observed that the keratinization pattern of trichilemmal cysts in two Japanese women may originate from the proliferation of the outer root sheath in the follicular isthmus of anagen hairs.
January 2021 in “Research Square (Research Square)” This study found that STAT3 directly inhibits the sheep FST gene and cell proliferation, shedding light on the molecular mechanisms of hair follicle development and wool characteristics.
207 citations
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July 2006 in “Development” This study identified a novel MTS24-positive murine keratinocyte population with increased colony-forming ability, suggesting these cells may serve as a new reservoir of proliferative progenitor or stem cells in hair follicles.
1 citations
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January 2020 in “Microscopy research” This study found that hair follicle stem cells from the bulge region in mice and humans can be isolated and cultured to maintain their phenotype and high proliferative capacity, suggesting their potential as an accessible source for tissue engineering and regenerative therapies.
This review discusses the unique characteristics and possible pathophysiology of spiny keratoderma, reporting no new clinical results, but suggests that some therapies might alleviate symptoms.
April 2025 in “ALEXMED ePosters” This study found that nanofat injections significantly improved scar characteristics, including collagen deposition, epidermal thickness, and vascularity, due to its anti-inflammatory and immunomodulatory properties.
7 citations
,
October 2020 in “Science and Innovations in Medicine” This review discusses how fibroblast metabolic processes and life span are influenced by the malate dehydrogenase shuttle system and highlights factors affecting fibroblast proliferative activity, without presenting new experimental results.
6 citations
,
July 2018 in “Advances in Clinical and Experimental Medicine” This study found that scalp hair follicles had higher expression of cytokeratin 15 and distinct hair layers compared to other body regions, highlighting differences in hair follicle characteristics.
October 2021 in “Journal of Investigative Dermatology” This study found that reconstructed human epidermis from infant skin is more susceptible to UV damage than that from older children, with notable changes in skin cell characteristics during the early years of life.
53 citations
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January 2013 in “Journal of toxicologic pathology” This publication provides a standardized nomenclature for classifying microscopic lesions in laboratory rat and mouse skin, aiming to harmonize international toxicological research.
May 2026 in “World Journal of Advanced Research and Reviews” This case report documents a rare instance of a trichilemmal cyst occurring on the plantar surface of the foot, highlighting the necessity of histological examination for accurate diagnosis when clinical or radiological presentations are atypical.
44 citations
,
July 2011 in “Dermato-endocrinology” This article reviews the skin condition myxedema associated with hypothyroidism, highlighting its characteristic non-pitting, glycosaminoglycan-rich nature, and reports no new results.
2 citations
,
July 2018 in “Chinese Journal of Dermatology” This study reported that imaging characteristics of sebaceous nevus vary significantly by age group, revealing dynamic developmental changes that can be effectively identified through dermoscopy and reflectance confocal microscopy, offering noninvasive diagnostic potential.
August 2026 in “npj Regenerative Medicine” This study found that hair follicle micro-graft transplantation significantly improved scar remodeling outcomes in 40 patients, with greater reductions in scar volume, lower scar scores, and enhanced skin characteristics compared to punch excision alone, potentially due to activation of the PI3K-AKT pathway.
6 citations
,
December 2017 in “Molecular Medicine Reports” This study found that Wnt5a expression may suppress cell differentiation and induce an inflammatory response in HaCaT keratinocytes, which could be relevant to psoriasis development.
April 2025 in “Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ” In this study, PRP significantly accelerated early wound healing in rabbits, with faster closure and improved tissue characteristics compared to controls, although both groups achieved near-complete healing by four weeks.
April 2018 in “Journal of Investigative Dermatology” This study found that the loss of transcription factor Ovol2 in epidermal and hair follicle stem cells leads to migration defects, which are partially improved by deleting the EMT-inducing Zeb1.
13 citations
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April 2020 in “Experimental Cell Research” This study found that knockdown of PCAT1 inhibited hair follicle regeneration in nude mice by disrupting the miR-329/Wnt10b axis and Wnt/β-catenin signaling, highlighting PCAT1's role in promoting follicle regrowth.
19 citations
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February 2022 in “Journal of Investigative Dermatology” Mechanical stretching can improve or hinder skin regeneration depending on duration.
1 citations
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January 2009 in “Journal of Dermatology and Venereology” This study found that cells from the upper hair follicle exhibited more active growth compared to other segments in vitro, suggesting their potential as a source of hair follicle stem cells.