Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that EP 2 signaling is crucial for macrophage recruitment and inflammatory regulation in the injured heart, impacting cardiac repair processes.

This study found that Xinyang Tablet may improve cardiac function in LPS-induced sepsis-induced myocardial dysfunction by modulating macrophage polarization and autophagy through affecting LncSICRNT1 and TRAF6 expression.

This study found that Acanthus ebracteatus extract and verbascoside induced dermal papilla cell proliferation and reduced inflammatory cytokine release in vitro, suggesting potential for anti-hair loss applications.

This study reports that beta-glucan hybrid hydrogels, reinforced with laponite nanoclay, showed promising results in rat models for managing hemorrhage and diabetic wound healing by enhancing hemostasis, reducing inflammation, and promoting faster wound closure and tissue regeneration.

In this study, tibial cortex transverse transport accelerated wound healing in diabetic rats, potentially through enhanced mobilization of non-classical monocytes and increased M2 macrophage polarization.

This study reported the development of a pH-responsive microreactor that effectively targets infections by eradicating over 99.9% of MRSA and reprogramming the immune response to promote healing, achieving complete infection clearance and tissue regeneration in a 7-day period.

In this study, researchers developed a hierarchically engineered microreactor that effectively combats infected wounds by releasing antimicrobials at acidic sites, eradicating MRSA while avoiding resistance, and enhancing tissue repair through immune system modulation.

This study found that HAMA hydrogels promote faster healing of skin wounds in mice by enhancing the accumulation of anti-inflammatory macrophages and increasing type III collagen in the local wound environment.

In this study, topical MR blockade improved delayed wound healing in glucocorticoid-pretreated mice by promoting anti-inflammatory macrophages and enhancing angiogenesis.

In this study, CD109 overexpression in transgenic mice led to reduced inflammation and improved collagen organization during wound healing without affecting wound closure.

In this study, HPH-15, a newly synthesized compound, demonstrated potential in reducing skin fibrosis in a mouse model by targeting underlying pathogenic mechanisms and exhibited a good safety profile, warranting further clinical trials for fibrotic skin disorders like systemic sclerosis.

This study introduced a multifunctional DNA hydrogel dressing that may enhance wound healing by promoting tissue regeneration, nerve repair, and immune response in diabetic infectious wounds.

This study presents a novel hydrogel scaffold made from tilapia collagen, which when activated by ultrasound, reprograms macrophages to promote wound healing, enhance angiogenesis, and stimulate hair follicle regeneration, offering a potential new method for treating inflammatory wounds.

In this study using a mouse model, researchers utilized single-cell RNA sequencing to create a comprehensive cellular atlas of infected versus uninfected wounds, revealing that Enterococcus faecalis infections lead to immunosuppressive changes in skin cells and disrupt normal wound healing processes.

This study found that magnesium oxide-incorporated electrospun membranes improved wound healing in a simulated model by accelerating wound closure, reducing inflammation, promoting fibroblast proliferation, and stimulating angiogenesis and skin regeneration.

This review discusses mechanisms of wound healing impairment in leptin-deficient murine models used for diabetic research, and reports no new clinical results; the authors emphasize the need for further study.

This study identified ISPP-Rb, a novel immuno-stimulatory complex from Royoporus badius, that significantly activates murine macrophage cells and induces multiple proinflammatory cytokines.

This review explores recent advances in inflammation resolution and considers how macrophage reprogramming might help address severe COVID-19 outcomes, particularly those involving cytokine storms, but it reports no new experimental results.

This study found that oral administration of Flammulina velutipes polysaccharide reduced tumor volume and improved survival in mice by modulating macrophage polarization and enhancing antitumor immune responses.

This study suggests that finasteride treatment may improve pulmonary immune response in mice following trauma and sepsis, indicating potential as a therapeutic option after major trauma.

This article discusses how designing biomaterials to modulate immune responses has become a promising strategy for enhancing tissue repair and regeneration.

This review highlights that unresolved inflammation is a major issue in diabetic foot ulcers and discusses emerging biomaterials-based strategies to modulate the inflammatory response, potentially aiding in tissue regeneration and healing in these chronic wounds.

This study found that adipose-derived mesenchymal stromal cell secretome, particularly when preconditioned with IFNγ, significantly influences cell motility and anti-inflammatory responses, enhancing its potential as a regenerative therapy.

This study characterized the inflammatory response in a promising murine model of thermal burns, similar to human burns, to inform future burn complication studies and preclinical testing of therapies.

This review discusses how studying regenerative biology in certain mammalian models could enhance our understanding of complex tissue regeneration, but it reports no new clinical findings.

This study characterized the inflammatory response in a murine burn model, revealing similarities to human burns and supporting the model's use in testing therapies for burn complications.

This review discusses recent advances in how proinflammatory cytokines affect epidermal stem cell function during skin wound healing and introduces potential therapies targeting these cells and cytokines.

This study found that macrophages near hair follicles contribute to the activation of skin epithelial stem cells in mice, suggesting a novel role for macrophages in regulating hair growth.

This study found that Schistosoma mansoni cercariae stimulate epidermal keratinocytes in mice, initiating pro-inflammatory responses and barrier repair mechanisms akin to those in wound healing.

This study found that reduced expression of CD200R1 on monocyte-derived macrophages in rheumatoid arthritis patients was significantly associated with higher disease severity and an imbalance in Th17/Treg cells.