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The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

The normal human prostate does not significantly affect blood DHT levels.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

New treatments for skin conditions related to the sebaceous gland are being developed based on current research.

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

A new method accurately measures steroid hormones in a few hair strands and could help study chronic stress and hair loss.

5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.

Phytotherapeutic compounds and supplements can help manage Polycystic Ovarian Syndrome (PCOS).

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

Gene mutations can cause problems in male genital development.

Natural products like propolis are causing more skin allergies, and certain skin treatments and medications have various side effects and risks.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

The new "differential stripping" method effectively measures how much substance gets into hair follicles.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Targeting hair follicles can improve skin treatments and reduce side effects.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.