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Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

The document concludes that careful evaluation is key to diagnose and treat women with hair loss, with tests for thyroid, iron, and hormones as needed.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Cationic polymers improved liposome stability and increased skin absorption of aciclovir and minoxidil.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Oral contraceptives help treat hyperandrogenic disorders, improving symptoms like excessive hair and acne.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Quercetin may help with PCOS symptoms, but more research is needed.

Herbs can potentially treat hair loss by inhibiting a key enzyme and promoting hair growth, and deficiencies in zinc, biotin, and iron are linked to hair loss.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.

Hair problems are common and distressing for women, but increasing knowledge of treatments offers hope.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Minoxidil effectively treats female pattern hair loss.

Hormone treatments can help with women's skin and hair disorders, but they need careful monitoring and more research.

Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.