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    Glossary Progenitor Cells

    cells that can differentiate into specific cell types but are more limited than stem cells

    Progenitor cells are a type of cell that has the capacity to differentiate into a specific type of cell but is more limited than a stem cell. Unlike stem cells, which can divide indefinitely and become any cell type, progenitor cells are already on the path to becoming a particular kind of cell and can only divide a limited number of times. They play a crucial role in tissue development and repair, including in the regeneration of hair follicles.

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    1. Nestin expression in hair follicle sheath progenitor cells Proceedings of the National Academy of Sciences · 2003 · 352 citations
    2. Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells Journal of Clinical Investigation · 2011 · 235 citations
    3. The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells Development · 2006 · 207 citations
    4. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014 · 149 citations
    5. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation Nature Communications · 2017 · 96 citations
    6. TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis The EMBO Journal · 2011 · 91 citations
    7. Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle The Journal of Cell Biology · 2005 · 53 citations
    8. Progenitor Cell Dysfunctions Underlie Some Diabetic Complications American Journal Of Pathology · 2015 · 46 citations
    9. Existence of Neural Crest–Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium American Journal Of Pathology · 2016 · 44 citations
    10. Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Cancer Research · 2017 · 38 citations
    11. Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies Journal of Cellular and Molecular Medicine · 2009 · 36 citations
    12. The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells Cell Reports · 2018 · 35 citations
    13. Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers Journal of Investigative Dermatology · 2013 · 33 citations
    14. Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair Stem Cell Reviews and Reports · 2016 · 24 citations
    15. Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies Experimental dermatology · 2021 · 19 citations
    16. Progenitor‐cell‐enriched micrografts as a novel option for the management of androgenetic alopecia Journal of Cellular Physiology · 2019 · 14 citations
    17. Defining microRNA signatures of hair follicular stem and progenitor cells in healthy and androgenic alopecia patients Journal of Dermatological Science · 2020 · 12 citations
    18. Progenitor cells expressing nestin, a neural crest stem cell marker, differentiate into outer root sheath keratinocytes Veterinary Dermatology · 2019 · 12 citations
    19. Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo Stem cell research & therapy · 2020 · 12 citations
    20. Enrichment and Characterization of Human Dermal Stem/Progenitor Cells by Intracellular Granularity Stem Cells and Development · 2013 · 10 citations
    21. Equine Hoof Stem Progenitor Cells (HPC) CD29 + /Nestin + /K15 + – a Novel Dermal/epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment Stem Cell Reviews and Reports · 2021 · 6 citations
    22. Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche Stem Cell Reports · 2024 · 3 citations
    23. PNKP is required for maintaining the integrity of progenitor cell populations in adult mice Life science alliance · 2021 · 3 citations
    24. Spatiotemporal Switches in Progenitor Cell Fate Govern Upper Hair Follicle Growth and Maintenance Journal of Investigative Dermatology · 2025 · 2 citations
    25. Enhancement of Progenitor Cells by Two-Step Centrifugation of Emulsified Lipoaspirates Plastic and Reconstructive Surgery · 2019 · 2 citations
    26. Aberrant connective tissue sheath contraction drives premature hair follicle regression by inducing progenitor cell depletion in androgenetic alopecia bioRxiv (Cold Spring Harbor Laboratory) · 2023
    27. Partial alopecia area retains bulge hair follicle progenitor cells in Indian androgenetic alopecia patients bioRxiv (Cold Spring Harbor Laboratory) · 2023
    28. Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    29. Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    30. Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023