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Nitric oxide is important for skin functions and both helps protect against and contributes to skin inflammation and sensitization.

HSD11b1 affects skin nerves and increases non-histaminergic itch.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Gray hair can potentially be reversed, leading to new treatments.

Prednisone reduces organ mast cell infiltration but does not alter the abnormal appearance of mast cells in systemic mastocytosis.

Scientists created keratinocyte cell lines from human hair that can differentiate similarly to normal skin cells, offering a new way to study skin biology and diseases.

Nuclear shape and chromatin changes affect gene expression in skin cell differentiation.

Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.

The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.

Human stem cells were turned into cells similar to those that help grow hair and showed potential for hair follicle formation.

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.

Heavy metals like arsenic, cadmium, and lead can increase cancer risk and worsen outcomes.

Drug repurposing speeds up development, cuts costs, and uses known safe drugs, but faces challenges like regulations and patents.

Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.

Manipulating cell cleanup processes could help treat hair loss.

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

Managing oxidative stress might help treat low testosterone and related chronic diseases in aging men.

The gene NM_026333 slows down aging by affecting the NCX1 pathway and could be targeted for anti-aging treatments.

OR2AT4 helps reduce aging and cell damage in human skin cells.

Stress may contribute to hair loss in alopecia areata by affecting immune responses and cell death in hair follicles.

New treatments for hair loss from alopecia areata may include targeting immune cells, using stem cells, balancing gut bacteria, applying fatty acids, and using JAK inhibitors.

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

Scientists are using clumps of special stem cells to improve organ repair.

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.

Baricitinib reduces inflammation and improves cell health in premature aging cells.

Activating Nrf2 can help protect against hearing loss.

Autophagy helps keep skin healthy and may improve treatments for skin diseases.

The UD-PrOZA program successfully diagnosed 18% of adult patients with rare diseases, often using genetic testing.