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In a rare case described by this source, a woman in her thirties was diagnosed with primary essential cutis verticis gyrata, a condition marked by thick scalp folds, after secondary causes were ruled out through clinical evaluations and biopsy.

In this study, researchers observed that a hidden scalp condition could contribute to acne keloidalis nuchae and potentially other primary cicatricial alopecias, impacting their diagnosis and treatment.

This article reviews strategies for managing the side effects of cytotoxic chemotherapy in primary healthcare settings and reports no new clinical findings.

This study found that cicatricial alopecia predominantly affects middle-aged Libyan females, with conditions like lichen planopilaris and discoid lupus erythematosus among the most common diagnoses.

This study observed that five cases of primary cicatricial alopecia showed an excellent response to a combination of oral zinc and long-pulsed Nd:YAG 1064-nm laser treatment, suggesting this approach may be beneficial for certain types of this condition.

This study found that Ift20 is essential for hair follicle stem cell identity and hair regrowth, and it regulates keratinocyte migration during wound healing through focal adhesion integrin recycling, independently of ciliogenesis.

This review discusses primary cicatricial alopecias, detailing their classification, pathogenesis, clinical features, histopathologic findings, and treatment, without reporting new experimental results.

A 4kb fragment of the desmocollin 3 promoter targets gene expression to specific skin and hair follicle areas.

This study evaluated the range and structure of medicinal products available for the treatment of primary cicatricial alopecias in Ukraine, revealing a significant reliance on imported products and a limited selection, which highlights potential for expanding and developing domestic production in this market segment.

This case study of a 43-year-old woman with primary hypothyroidism found that an integrated Ayurvedic treatment over 20 weeks led to normalized thyroid function and relief of hypothyroid symptoms, highlighting Ayurvedic therapy's potential role in managing the condition.

In this case study, a 23-year-old man initially suspected of having minoxidil-induced pericarditis was ultimately diagnosed with cardiac angiosarcoma, highlighting the need to consider malignancy in cases of recurrent pericarditis in young adults.

This review suggests that 308 nm excimer therapy may offer a well-tolerated non-pharmacologic option for alopecia areata, with more limited evidence for its effectiveness in lichen planopilaris and frontal fibrosing alopecia.

This article notes the lack of US prevalence data for primary lymphocytic cicatricial alopecias due to the recent introduction of subtype-specific ICD-10 codes and highlights the importance of early diagnosis for hair preservation.

This case report describes a rare occurrence of primary cutaneous diffuse large B-cell lymphoma, not otherwise specified (PCDLBCL-NOS) on the scalp of a 45-year-old female, highlighting its unusual presentation and the initial treatment response but also noting severe subsequent complications.

The researchers reported a case of a 51-year-old woman with primary hypothyroidism who developed anaphylaxis to intravenous levothyroxine after being unresponsive to oral formulations, highlighting potential allergic reactions to IV treatments in such patients.

This case report presents a rare instance of recurrent ACTH-independent Cushing’s syndrome due to PBMAH, coinciding with the development of a pheochromocytoma, highlighting the need for thorough reevaluation in similar recurring cases.

In this study, cicatricial alopecias were classified by inflammatory cell type and the researchers highlighted that primary cicatricial alopecia's exact causes remain unknown, accounting for 6% of all hair diseases despite its unclear prevalence.

This study suggests that autologous platelet concentrates may improve inflammatory activity, disease control, and hair regrowth in primary cicatricial alopecia, but the evidence is limited by small sample sizes and study quality.

Lasheras-Pérez et al. reported that JAK3 and TYK2 proteins are activated in certain forms of primary cicatricial alopecia, suggesting the JAK/TYK/STAT pathway as a potential therapeutic target for these conditions.

This review found that hair transplantation in patients with primary cicatricial alopecias is a viable option when the disease is stable, with outcomes varying significantly by subtype.

In this case study, a 24-year-old woman with frontal alopecia resembling frontal fibrosing alopecia was ultimately diagnosed with primary cutaneous follicle center lymphoma, highlighting the critical role of biopsy in identifying atypical alopecia presentations.

This study found that patients with primary cicatricial alopecia are at higher risk of developing various comorbidities, including systemic lupus erythematosus, hypothyroidism, and dermatological conditions, compared to controls.

This study reported that the combination of tacrolimus, clobetasol, and minoxidil improved hair measurements and stabilized inflammation in primary cicatricial alopecia patients, with most tolerating the treatment well.

Scarring alopecia involves increased immune cells and specific gene changes near damaged hair follicles.

Specific immune cells and pathways contribute to hair follicle inflammation and hair loss, suggesting potential treatments for lichen planopilaris.

This review analyzed literature on primary cutaneous lymphomas involving the scalp, finding that scalp involvement in these cases often leads to non-scarring focal alopecia and may indicate more aggressive disease.

In this retrospective chart review, researchers found that patients with scarring alopecia, including central centrifugal cicatricial alopecia, have a higher prevalence of various systemic comorbidities, such as vitamin D deficiency and metabolic syndrome, compared to the general US population.

This literature review found that Janus kinase inhibitors may help achieve remission in patients with refractory primary neutrophilic cicatricial alopecias, though data is limited to small case series and reports.

This report emphasizes the importance of considering thyroid tuberculosis in the differential diagnosis of cervical masses, highlighting the role of biopsy and histopathological examination for accurate diagnosis and treatment.

This study explored how T cells interact with hair follicles in primary cicatricial alopecias by using spatial transcriptomics across mice, dogs, and human samples, revealing specific communication pathways and potential drug targets like CFD and S100A8/9 for future therapeutic research.