37 citations
,
November 2002 in “Biology of Reproduction” This study found that prenatal antiandrogen treatment in female spotted hyenas significantly altered the LH response to GnRH, indicating partial masculinization of their anterior pituitary gland without affecting ovulatory function.
40 citations
,
January 2013 in “Frontiers in Endocrinology” Finger length ratios are not linked to the number of specific gene repeats affecting testosterone sensitivity.
22 citations
,
May 1986 in “Clinics in endocrinology and metabolism” This study found that women with lower 2D:4D ratios and fewer middle-phalangeal hairs reported more adverse side effects from oral contraceptives, suggesting these features may predict hormonal contraceptive side effects.
118 citations
,
May 2003 in “Toxicological Sciences” This study found that prenatal exposure to finasteride in rats led to permanent changes in developmental endpoints like anogenital distance and nipple retention, which were predictive of further reproductive tract malformations.
26 citations
,
November 1993 in “Progress in Neuro-psychopharmacology & Biological Psychiatry” This study reported that prenatal exposure to dihydrotestosterone altered long-term androgen metabolism in juvenile male rats, suggesting different regulatory mechanisms for 5a-reductase in hypothalamic versus pituitary tissues.
24 citations
,
January 2021 in “Physiological Research” This review addresses the effects of testosterone on brain development and examines both the established sex differences in brain functions and the debate surrounding structural dimorphism in neuropsychiatric conditions.
54 citations
,
March 2012 in “International Journal of Andrology” This study found that prenatal exposure to certain pesticides may lead to earlier breast development in girls, potentially associated with higher androgen levels.
51 citations
,
August 2012 in “Differentiation” This study found that penile and clitoral differentiation in mice is influenced by androgen exposure, with penile features developing postnatally requiring prenatal and ongoing androgen presence.
72 citations
,
October 1998 in “Baillière's clinical endocrinology and metabolism” This article discusses the potential effects of exogenous testosterone, highlighting that its impact on prostate cancer progression, cardiovascular health, and behavior remains uncertain and needs further investigation.
25 citations
,
June 2012 in “Endocrine” This review discusses emerging concepts in PCOS from the AEPCOS 2010 meeting and reports no clinical findings; it suggests that the transition of care in congenital adrenal hyperplasia could inform PCOS adolescent care.
6 citations
,
October 2018 in “Endocrinology” This study indicates that sheep prenatally androgenized with testosterone show wool fiber diameter changes that parallel the increased hair diameter in women with polycystic ovary syndrome.
186 citations
,
February 2015 in “Frontiers in Neuroscience” This review discusses the complex effects of testosterone on the brain, emphasizing sex differences, and reports no clinical results; the authors highlight the inconsistencies in current study findings.
32 citations
,
February 2017 in “Human Reproduction” This study found that women with PCOS were more likely to have longer anogenital distances, indicating possible intrauterine origins linked to prenatal androgen exposure.
143 citations
,
August 1991 in “Endocrinology” This study found that blocking androgen receptors inhibits testicular descent in rats more effectively during the early stages of gubernacular outgrowth than inhibiting 5a-reductase.
34 citations
,
July 2020 in “Frontiers in immunology” This mini-review discusses the role of androgens, specifically testosterone and dihydrotestosterone, in the pathogenesis of autoimmune liver diseases and reports no new results.
18 citations
,
March 2020 in “Frontiers in Neuroendocrinology” This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.
3 citations
,
March 2024 in “Frontiers in Cell and Developmental Biology” This study observed that both prenatal androgen exposure and postnatal early-life environment influence the development of PCOS-like phenotypes and changes in the gut microbiota in prenatally androgenized offspring.
4 citations
,
May 2019 in “Physiology & Behavior” This study found that cocaine disrupted the relationship between certain brain androgen levels and sexual behavior in male rats, with dose-dependent effects on testosterone metabolism.
2 citations
,
August 2016 in “Experimental Dermatology” This review discusses the efficacy and safety of oral finasteride for treating male pattern baldness and the potential persistent side effects, but no new results are reported.
1 citations
,
June 2022 in “Frontiers in Neuroanatomy” This study found that neonatal blocking of androgen and estrogen pathways in rats altered sex-specific expression of estrogen and androgen receptors in adult pituitary and adrenal glands, potentially influencing lifelong neuroendocrine function.
991 citations
,
January 2011 in “Nature Reviews Endocrinology” This paper reviews the diagnostic criteria, associated morbidities, and possible evolutionary advantages of polycystic ovary syndrome, but does not report any new findings.
658 citations
,
June 2003 in “Endocrine reviews” This review discusses the role of androgens in the progression of cardiovascular disease and explores novel therapeutic targets without reporting new clinical results.
9 citations
,
February 2022 in “Biomedicines” This study suggests that testosterone therapy in AFAB individuals may modify the methylation of the ESR2 promoter, with changes influenced by factors like total testosterone levels and age.
October 2020 in “Authorea (Authorea)” This review discusses the influence of androgens on opioid-mediated effects and calls for further research into their role in sex differences and potential therapeutic options for chronic pain and substance use disorders.
25 citations
,
March 2000 in “Journal of Endocrinological Investigation” Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.
In this systematic review, researchers observed that Toxoplasma gondii infection is associated with alterations in testosterone levels, generally increasing in humans but showing mixed effects in animals, highlighting a complex relationship that warrants further investigation.
8 citations
,
March 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” In this study of healthy men, low levels of testosterone and dihydrotestosterone were associated with higher body mass index, fat content, and insulin resistance, but their effects on lipid and glucose metabolism were similar in quality.
1 citations
,
October 2017 in “Elsevier eBooks” This review examines the effects of antiandrogens on female reproductive systems, particularly regarding environmental endocrine disruptors, and presents no new research findings.
16 citations
,
October 2007 in “Andrologia” This study suggests that DHT may have a less potent effect on the prostate compared to testosterone while maintaining safety and similar effects on erythropoiesis and lipids.
28 citations
,
May 2015 in “Addiction Biology” This study found that early life stress significantly affects hedonic sensitivity to high-palatable food by altering gonadal hormones in prenatally-stressed male and female rats, with sex-dependent changes in reward-related behaviors and neurochemistry.