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This study suggests that stress-induced premature senescence of dermal papilla cells may contribute to hair follicle aging by impairing critical epithelial-mesenchymal interactions and promoting inflammatory cytokine production.

This study found that exposure to phytoestrogens, bisphenol A, parabens, and phthalates was associated with developing idiopathic premature thelarche in girls.

This study found that estrogen treatment induced premature catagen and apoptosis in hair follicles of wild-type mice, while having no effect on mice lacking estrogen receptor α.

This study found that young Indian smokers with hypertension, central obesity, diabetes mellitus, and metabolic syndrome show a higher risk for premature acute coronary artery disease compared to those without these conditions.

This study found that male Indian patients under 30 with early androgenetic alopecia were more likely to have metabolic syndrome compared to age-matched controls.

This review explores the factors contributing to premature graying of hair, highlighting the role of genetic and environmental influences such as oxidative stress, and discusses potential interventions like diet and herbal remedies, while noting the limitations of common treatments like hair dyes.

This study identified a novel SCF mRNA splice variant in white merino sheep skin, which may play a role in hair follicle melanogenesis.

This article reviews current understanding of Hutchinson–Gilford Progeria Syndrome and suggests RNA-based treatments show promise, but no new clinical findings are reported.

This study found that different stressors causing premature senescence in fibroblasts resulted in distinct changes in lipid profiles, particularly sphingolipids, which may affect the behavior of senescent skin cells.

Men with early hair loss may have a higher risk of enlarged prostate and possibly prostate cancer due to shared hormonal factors.

Finasteride, a hair loss medication, was found to be safe and effective in improving hair quality and stopping hair loss in men with early-onset baldness.

This review discusses the relationship between polycystic ovary syndrome and cardiovascular risk, noting a possible adverse impact on risk profiles and subclinical atherosclerosis but no clear increase in premenopausal cardiovascular events; it presents no new clinical results.

In this study, researchers reported that chronic UV exposure may contribute to androgenic alopecia progression by influencing hair cycle changes and exacerbating solar elastosis in the scalp.

In this study, decreased levels of SHBG and a high free androgen index were observed in men with severe premature baldness compared to controls, but this condition was not equivalent to PCOS or metabolic syndrome in females.

This study found that loss of the ACER1 gene in mice led to increased ceramide levels and progressive hair loss, highlighting ACER1's role in maintaining hair follicle stem cell homeostasis.

This study found a significant correlation between vitamin D deficiency and the severity of androgenetic alopecia in males, suggesting that vitamin D may influence the condition's premature onset.

In this study on mouse preputial glands, suppressing ATG7-dependent autophagy delayed age-related changes, affected lipid metabolism, and reduced pheromone production, highlighting autophagy's roles in glandular homeostasis and cell breakdown.

This study found that in mice with premature ovarian insufficiency, miR-21 enhances ovarian function recovery following umbilical cord-derived mesenchymal stem cell transplantation by influencing specific cellular signaling and immune pathways.

In this study, researchers found that young men with premature androgenetic alopecia had a hormonal profile similar to the pattern seen in women with polycystic ovary syndrome, suggesting a possible genetic link.

This report describes a novel AR gene mutation in a female patient, contributing to androgen insensitivity syndrome, and emphasizes its potential impact on genetic counseling.

This study found that the free androgen index (FAI) is a superior marker of hyperandrogenism in men with premature androgenetic alopecia compared to DHEAS and testosterone levels.

In this study, researchers found a significant decrease in the modulus of elasticity of hair shafts in premature neonates compared to full-term ones, potentially due to differences in disulphide bonds or microfibril arrangement.

This study in diabetic db/db mice found that treatment with the antihypertensive agents minoxidil or nebivolol stimulated elastogenesis and inhibited elastolysis, leading to restored elastic fibers, reduced aortic stiffening, and normalized blood pressure.

This study found that targeting connective tissue sheath contraction with an MLCK inhibitor may improve hair growth in androgenetic alopecia by reducing premature hair regression caused by ectopic apoptosis of hair follicle progenitor cells.

This study found that dysregulation of the DNA damage response in stem cells is a common factor of aging, affecting tissues like the skin, brain, kidneys, and intestine.

This study found that inhibiting autophagy in mouse preputial glands alters lipid metabolism, delays aging-related duct changes, and reduces pheromone production, indicating autophagy's critical role in gland homeostasis and cell breakdown during secretion.

This study found that autophagy in the preputial glands of mice plays a crucial role in regulating lipid and fatty acid metabolism, as well as pheromone production.

This study found that girls with isolated premature thelarche, confirmed by GnRH stimulation test, aged 4-8 years, may have significantly advanced bone age, with obesity and serum IGF-1 and DHEAS levels being key risk factors.

This study found that estrogen can cause reversible suppression of the hair cycle by inducing premature catagen and maintaining the telogen phase without damaging the hair follicle stem cell niche or the signature gene expressions of dermal papilla cells.

This study found that the DPP-4 inhibitor linagliptin slowed the progression of premature aging characteristics in klotho-/- mice, including improved body weight, cognitive function, and hair retention.