June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, a herbal hair serum formulated with Phyllanthus emblica, Murraya koenigii, Eclipta alba, and Mangifera indica in sesame oil showed promising antioxidant properties and scalp protection, potentially delaying premature hair greying.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study formulated a herbal hair serum with ingredients like Phyllanthus emblica and Murraya koenigii that showed promising antioxidant and scalp-protective properties, potentially helping to delay premature hair greying. The serum demonstrated acceptable physicochemical properties, lacked skin irritation effects, and exhibited effective radical scavenging activity.
June 2026 in “Quality in Sport” This narrative review analyzed the literature on premature hair graying, identifying potential contributors such as nutrient deficiencies, oxidative and emotional stress, smoking, genetic factors, autoimmune diseases, and medication side effects, but reported no effective treatment to reverse it, underscoring the necessity for further research.
June 2026 in “International Journal of Drug Delivery Technology” This review explores the potential of herbal therapies and modern delivery methods for managing premature hair greying, highlighting promising plant-based treatments and emphasizing the need for clinical trials to validate their effectiveness.
May 2026 in “Archives of Dermatological Research” In this study, serum levels of vitamin C, vitamin E, and total antioxidant capacity did not differ significantly between individuals with premature greying hair and controls, but a strong association with family history was observed.
April 2026 in “BMC Women s Health” This study in Urmia, Iran, characterized women with PCOS, POF, and EMs, revealing a PCOS prevalence of 17.69% and emphasizing significant lifestyle and health differences compared to healthy individuals, particularly in rural areas, alongside identifying key screening features for POF and EMs.
April 2026 in “Indian Dermatology Online Journal” This study found that individuals with premature graying of hair in India had significantly lower levels of serum ferritin, vitamin B12, and vitamin D3 compared to controls.
March 2026 in “Journal of Health Wellness and Community Research” In this study of young adults in Lahore, Pakistan, researchers reported a 55.2% prevalence of premature graying before age 30, commonly linked with factors like family history, nutritional deficiencies, hair loss, oily scalp, anxiety, and smoking.
March 2026 in “International Journal of Homoeopathic Sciences” In this study, 10.25% of school children aged 5-15 in Belagavi were found to have premature greying of hair, with the majority showing mild severity according to the Graying Severity Score.
January 2026 in “Medicina” This study conducted among medical students in Saudi Arabia found a 37.2% prevalence of premature hair graying and associated it with smoking, a keto diet, hair coloring, and family history, while suggesting that lifestyle changes may reduce its impact.
January 2026 in “International Journal of Science and Research Methodology” This review explored the therapeutic potential of Bhangra (Eclipta alba) for treating premature greying of hair, noting the plant's melanogenic, antioxidant, and revitalizing properties, but highlighted the need for further research to scientifically support its effectiveness.
December 2025 in “GARI International Journal of Multidisciplinary Research” This study examines Ayurvedic approaches to managing premature hair greying, highlighting the potential of herbal formulations, lifestyle interventions, and rejuvenative therapies as safe, sustainable alternatives, though more rigorous clinical trials are needed to validate these methods.
December 2025 in “Journal of Ayurveda and Integrated Medical Sciences” This article discusses the ancient Ayurvedic explanations of premature greying, or Akala Palitya, highlighting how modern lifestyle factors like stress and pollution have increased its prevalence, particularly in urban and developing areas.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review explores the causes and management of premature greying in children, noting it may indicate underlying health issues, and emphasizes structured evaluations and treatments, particularly for nutritional deficiencies and hypothyroidism, to address hair depigmentation.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights concerns around premature greying in children, detailing possible links to nutritional deficiencies and other health issues, and emphasizes that structured evaluation and targeted treatment may aid in reversing the condition.
November 2025 in “World Journal of Biology Pharmacy and Health Sciences” This review reported that premature greying in children, which can indicate certain deficiencies or disorders, may be addressed through a structured evaluation and treatment targeting factors like vitamin B12 and iron deficiencies or hypothyroidism, providing a practical approach for pediatric care.
October 2025 in “International Journal of Homoeopathic Sciences” In this case report, a 5-year-old boy with premature greying and thinning of hair experienced reduced thinning and regained normal pigmentation after seven months of treatment with the homeopathic remedy Natrum muraticum.
July 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” This review assessed the role of scalp hair Survivin protein in individuals with premature graying, exploring its potential involvement in graying-related processes and highlighting its overexpression in autoimmune diseases that may influence the survival of specific immune cell clones.
June 2025 in “Bioinformation” This study found that nearly one in four young adults in a dermatology clinic had premature greying of hair, influenced by genetic factors, lifestyle, and micronutrient levels.
June 2025 in “British Journal of Dermatology” This study investigated premature greying and found lower levels of vitamin D and vitamin B12 in affected individuals compared to controls, associating micronutrient deficiencies with altered hair pigmentation, though no significant link between micronutrient deficiencies and inflammatory markers was observed.
June 2025 in “V F Snegirev Archives of Obstetrics and Gynecology” In this case study, a six-year-old girl was diagnosed with isolated adrenarche, linked to premature adrenal maturation, with increased dehydroepiandrosterone sulfate and axillary and pubic hair growth, and will require long-term monitoring due to increased risks of conditions like polycystic ovary syndrome and cardiovascular diseases.
This study observed that premature hair graying was more prevalent among obese individuals, those with vitamin B12 and D deficiencies, smokers, and people with high stress, regardless of whether they were medical or non-medical students at a university in Saudi Arabia.
April 2025 in “Dermatology Practical & Conceptual” In this study, researchers observed that individuals with premature graying of hair had significantly higher LC3 gene expression compared to controls, suggesting a potential link between autophagy and the development of this condition, with LC3 gene expression as a possible independent predictor.
February 2025 in “Folia Medica” This study found that men with androgenetic alopecia had significantly lower serum vitamin D levels compared to controls and the deficiency strongly correlated with the severity of the condition.
January 2025 in “International Journal of Herbal Medicine” In this case study, a 27-year-old male with premature greying of hair saw significant improvement in hair whitening after ten weeks of treatment with Unani formulations, despite no family history or systemic disorder.
December 2024 in “Current Cosmetic Science” This review introduces Ayurvedic remedies as a promising natural treatment for premature greying of hair, highlighting the use of Vedic plant taxonomy to accurately identify herbs that stimulate melanogenesis and restore hair pigmentation, offering a safer alternative to conventional chemical treatments.
November 2024 in “Jurnal Biomedika dan Kesehatan” This study explores premature graying of hair, outlining potential causes such as genetic factors, nutritional deficiencies, and autoimmune disorders, and evaluates various management strategies including nutritional supplements, pharmacotherapy, and addressing underlying conditions.
October 2024 in “Journal of the Pakistan Medical Association” This letter discusses the various risk factors associated with premature greying of hair, highlighting genetic predispositions, nutritional deficiencies, stress, and lifestyle factors, while noting a lack of conclusive data on effective interventions, as detailed in the reviewed studies.
October 2024 in “Journal of Cosmetic Dermatology” This study in Saudi Arabia found that 55.9% of participants reported premature graying of hair before age 30, with risk factors including genetic, health, and lifestyle aspects such as smoking, anxiety, nutrient deficiencies, and family history.
This review discusses the role of nutrients in hair graying management and finds a possible link between low copper, iron, and vitamin B12 levels and premature hair graying.