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The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Reduced AR gene methylation may cause early pubic hair growth in girls.

Premature hair graying in young men is linked to family history, obesity, and smoking.

Premature ovarian insufficiency (POI) can harm women's sexual health, and they may benefit from hormone therapy and counseling.

Early adrenal gland maturation in young children can be normal, but other serious conditions should be ruled out first.

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

Studying premature aging syndromes helps understand human aging and suggests potential treatments.

Men with early balding often have hormone levels similar to women with polycystic ovary syndrome.

Premature hair graying in young Turkish adults is more likely if they have stress, a family history of graying, drink alcohol, have chronic diseases, are older, or are taller.

Premature balding in some men may be linked to altered hormones, but it's not the male equivalent to polycystic ovary syndrome or metabolic syndrome.

The fuzzy gene is crucial for controlling hair growth cycles.

Premature hair graying may be a sign of increased risk for heart disease, indicating biological age is more important than actual age.

Early hair whitening may indicate a higher risk of heart disease in young and middle-aged men.

Balding men had lower bone density, while balding women had higher hip bone density.

Some men with early hair loss may have similar hormonal changes to women with Polycystic ovary syndrome, and could be at risk for developing type 2 diabetes.

Low birthweight and rapid weight gain after birth may increase the risk of developing polycystic ovary syndrome.

Premature graying of hair is linked to various health issues and can sometimes be reversed by treating underlying conditions.

Early shedding of the inner root sheath in noninflamed hair follicles is a relatively specific sign of Central Centrifugal Cicatricial Alopecia.

Premature hair greying may indicate a higher risk of metabolic problems.

Chemotherapy caused a woman's permanent hair loss and early menopause.

A rare combination of halo nevi, nonsegmental vitiligo, and early gray hair can occur together.

Premature hair loss doesn't increase the risk of metabolic syndrome.

Early balding, premature graying, and hair thinning can predict heart disease in young Asian males.

Women with premature ovarian insufficiency have a worse cardiovascular risk profile than premenopausal women.

Removing Dicer from pigment cells in newborn mice causes early hair graying and changes in cell migration molecules.

Ayurveda suggests natural treatments for premature hair greying caused by an imbalance of Pitta dosha.

A woman's premature gray hair turned mostly black again after using Greyverse solution and hair supplements for 5 months.

Low iron levels are linked to premature graying of hair, but vitamin D levels are not.

Lead and selenium levels don't cause premature graying.

Genetics, nutrition, lifestyle, and hormones affect early grey hair, but more research is needed.