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Early diagnosis and treatment of PCOS in teenagers can help prevent more severe adult PCOS.

Finasteride worsens stress effects on sensory processes, possibly linking to anxiety/depression.

Finasteride blocks progesterone production in specific tumor cells, potentially causing side effects.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

A boy with a new NR5A1 gene mutation has a sex development disorder without affecting his adrenal glands.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Higher levels of unbound testosterone are linked to increased insulin resistance, especially in women with polycystic ovary syndrome.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

New genes and pathways are important for testosterone production and male sexual development.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

DHT, a testosterone byproduct, causes male pattern baldness.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.