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New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Certain drugs that block specific enzymes can help treat prostate diseases.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Quercetin may help with PCOS symptoms, but more research is needed.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Sex hormones affect brain injury differently in males and females.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Researchers developed a reliable way to measure hormones in urine, showing that a baldness treatment doesn't change hormone levels.