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New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Early NAS level changes affect alcohol consumption vulnerability.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Finasteride worsens stress effects on sensory processes, possibly linking to anxiety/depression.

Allopregnanolone changes gene expression in glioblastoma cells.

Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Vitamin D is important for bones, hair, blood pressure, and breast development.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Finasteride may lower cholesterol and slow heart disease progression.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

New genes and pathways are important for testosterone production and male sexual development.

St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.

Natural volatiles and essential oils have health benefits and can enhance the effects of some medicines, but more research is needed to understand how they work and their possible side effects.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.