11 citations
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May 1996 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study reported that 5 alpha-reductase type 2 is the predominant enzyme in pubic skin fibroblasts across normal men, women, and hirsute patients, suggesting potential treatment options for idiopathic hirsutism.
3 citations
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January 2023 in “JEADV Clinical Practice” This study suggests that IL-17 may play a more significant role than IFN-γ in the pathogenesis of chronic alopecia areata, with increasing severity linked to Th17 lymphocytes and cytotoxic T lymphocyte infiltration.
2 citations
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June 2025 in “Journal of Investigative Dermatology” CD8+ T cells re-expressing CD45RA may predict treatment resistance in severe alopecia areata.
81 citations
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September 2005 in “The American journal of pathology” This study found that activin affects both stromal cells and keratinocytes in skin morphogenesis and repair, with dose-dependent effects on keratinocytes demonstrated through transgenic mouse models.
56 citations
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December 2002 in “The Journal of Clinical Endocrinology & Metabolism” This study suggests that in human osteoblast-like cells, the 5alpha-reductase type 1 isozyme predominantly catalyzes the conversion of testosterone to DHT, which may play a role in bone homeostasis.
2 citations
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August 2023 in “Experimental Dermatology” In this study, researchers discovered that HEY2+ dermal papilla cells exhibit stemness and contribute to dermal regeneration during wound healing, as shown by the expression of a reporter gene in regenerated dermal cells of tamoxifen-induced transgenic mice.
1744 citations
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August 2006 in “The Journal of Clinical Endocrinology and Metabolism” This review discusses definitions of polycystic ovary syndrome and reports no new clinical results; the authors support using modified 1990 NIH criteria and acknowledge ongoing evolution as research advances.
34 citations
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July 2020 in “Frontiers in immunology” This mini-review discusses the role of androgens, specifically testosterone and dihydrotestosterone, in the pathogenesis of autoimmune liver diseases and reports no new results.
27 citations
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April 2017 in “British Journal of Dermatology” This study identified overexpression of certain immune-related genes and underexpression of genes in specific signaling pathways in premature androgenetic alopecia, suggesting potential new therapeutic targets.
14 citations
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December 2020 in “Journal of The American Academy of Dermatology” This study observed a significant increase in telogen effluvium cases among people of color during the COVID-19 pandemic in NYC, notably affecting Hispanic/Latinx individuals.
8 citations
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June 2016 in “PubMed” This review discusses the use of finasteride for treating hidradenitis suppurativa and reports favorable outcomes in several cases, suggesting it could be an effective and safe option for certain patients.
5 citations
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February 2015 in “Journal of Comparative Pathology” This study suggests that high proliferative activity and peripheral invasion are key indicators of malignancy in canine sebaceous gland tumours. It also reports a higher incidence of circumanal gland and testicular tumours, indicating a possible androgen-related pathway in tumour development.
April 2024 in “European Journal of Dermatology” This study suggests that the PPP2R3C gene may confer susceptibility to psoriatic arthritis and psoriasis vulgaris in Chinese patients, with additional possible associations involving IL-23R, ERN1, IFIH1, and KIF3A genes.
April 2013 in “The Journal of Urology” Higher CRP levels suggest chronic inflammation is linked to bladder-related urinary symptoms in men with enlarged prostates.
January 2007 in “Yearbook of Dermatology and Dermatologic Surgery” Intramuscular triamcinolone and pulse therapy with oral predonine are effective for alopecia areata with manageable side effects, but better relapse prevention is needed.
1 citations
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October 2018 in “InTech eBooks” This article reviews treatment approaches for cicatricial alopecia, describing how medication efficacy varies and suggesting autologous hair transplantation for stable cases; no new clinical data are presented.
November 2022 in “JAAD case reports” This report diagnosed a 68-year-old man with comedonal folliculotropic mycosis fungoides based on clinical and histopathological findings, and found pegylated interferon alpha-2a with isotretinoin beneficial in reducing skin lesions.
37 citations
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September 2008 in “The American journal of surgical pathology” This study concluded that hair follicle hyperplasia found in pseudolymphomatous folliculitis can also occur in genuine cutaneous lymphomas, potentially as a coincidental result of underlying pathological processes.
37 citations
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August 1991 in “International Journal of Dermatology” This study reported a predominance of adult patients, mostly women, with Trichophyton violaceum tinea capitis in southern Taiwan, noting a bimodal age distribution and questioning whether this represents a new trend.
July 2022 in “Dermatology Reports” This review found a predominance of low serum zinc levels across various skin disorders, indicating possible value in further investigating zinc supplementation as an adjunctive therapy.
155 citations
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September 2008 in “British journal of dermatology/British journal of dermatology, Supplement” This study observed that frontal fibrosing alopecia predominantly affects postmenopausal women, can be associated with lichen planus, and may lead to progressive hairline recession, though this progression is not consistent in all cases.
55 citations
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February 2014 in “Journal of Structural Biology” This study observed that human hair macrofibrils predominantly exhibit a double-twist architecture with varying inter-macrofibril angles, advancing insights into their structural organization and mechanical implications.
52 citations
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April 2012 in “Journal of Investigative Dermatology” This study found that KRTAP2 proteins predominantly express in the hair shaft cortex of humans, interact with hair keratins, and play crucial roles in hair shaft keratinization.
45 citations
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September 1998 in “Journal of Investigative Dermatology” This study found that sebaceous glands predominantly exhibit oxidative activity of the type 2 17β-hydroxysteroid dehydrogenase isozyme, which is not inhibited by 13-cis retinoic acid.
25 citations
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April 2012 in “Acta Biomaterialia” This study observed that NSPC predominantly differentiated into neurons when exposed to serum fractions with molecules under 100 kDa, particularly with biomaterial and fibronectin, in the presence of basic fibroblast growth factor.
1 citations
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June 2025 in “Journal of Clinical Medicine” This study reported that frontal fibrosing alopecia predominantly affects postmenopausal women and identified potential risk factors like frequent β-blocker use and sunscreen application, indicating the need for further research.
1 citations
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July 2020 in “Iberoamerican Journal of Medicine” This study found that cicatricial alopecia predominantly affects middle-aged Libyan females, with conditions like lichen planopilaris and discoid lupus erythematosus among the most common diagnoses.
October 2025 in “Italian Journal of Dermatology and Venereology” This study reported that lichen planopilaris predominantly affects females over 60, with a registered prevalence rate of 0.02581%, and is often associated with autoimmune diseases like systemic lupus erythematosus, suggesting a need for further research to enhance treatment approaches.
September 2025 in “Journal of Ayurveda and Holistic medicine.” This review interprets PCOS as a kapha-predominant disorder within the Ayurvedic framework, characterized by medoduṣhṭi, a feeble state of rasa dhatvagni, and margavaraṇa, but reports no new clinical results.
September 2024 in “Cureus” This study found that systemic lupus erythematosus predominantly affects young adults, with diverse symptoms including mucocutaneous and renal involvement, and highlights the significance of early detection for improved management.