Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that mixtures used in permanent hair dyes had irritant effects on reconstructed human epidermis, while individual ingredients alone did not.

This study found that finasteride selectively inhibited UGT1A4 in vitro but is unlikely to cause clinically significant drug interactions mediated through hepatic UGT enzymes in vivo.

In this study, clozapine reduced suicide-related behaviors in a schizophrenia-like mouse model, but its effects on exploratory behavior were counteracted by the neurosteroid inhibitor finasteride.

This study found that a high-energy shock wave can increase osteogenic activities in human mesenchymal cells, offering insights into potential therapeutic targets for trauma-induced heterotopic ossification.

This study identified key genes related to ischemic stroke through the ferroptosis pathway and highlighted the potential role of specific traditional Chinese medicines in regulating associated biological processes.

This preclinical study found that exercise-induced extracellular vesicles delayed breast cancer tumor growth in mice, potentially by enhancing the immune response within the tumor microenvironment.

This study found that in female dogs, exposure to free fatty acids increased androgen production, suggesting a potential link to factors characteristic of polycystic ovary syndrome.

This study suggests that administering SH-MSCs gel might decrease IL-6 expression and increase TGF-β expression in alopecia-like rats, indicating potential for alopecia therapy.

This study explored the use of "microfollicles," a human hair follicle organoid model, as an in vitro tool for testing hair-growth substances, finding up to 75% overlap in gene expression changes with human clinical biopsy responses to minoxidil, indicating its potential for pre-clinical substance testing.

This narrative review found that while AI-based tools in dermatology, particularly for hair disorder assessment, have potential to enhance clinical practice by improving objectivity and personalization, they currently serve mainly a complementary role and face challenges like methodological limitations and data bias.

This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.

This study assessed minoxidil solubility in propylene glycol and water mixtures, comparing cosolvency models and examining thermodynamic properties, without reporting new clinical results.

This study concluded that specific SNPs in the TRPS1 gene significantly alter its protein structure, affecting interactions and contributing to the development of congenital hypertrichosis.

Machine learning is effective in predicting gene functions and their relationships with diseases.

This study suggests that the TNF-α system may contribute to hyperandrogenism, obesity, and insulin resistance in polycystic ovarian syndrome, independent of the C850T polymorphism.

In this review, researchers summarize key factors in constructing skin organoids, including cell source and assembly methods, and emphasize advances such as air-liquid interface culture for improving tissue development, aiming to guide standardized protocols and future clinical applications.

This review discusses the applications and potential of Bioengineered Artificial Skin Substitutes in cosmetics and pharmacology research, with no new clinical findings reported.

This article reviews insights into the pathogenesis of primary cicatricial alopecias, such as lichen planopilaris, provided by emerging technologies, but it does not report new clinical results.

This study found that minoxidil exhibits preferential solvation by water in both water-rich and ethanol-rich solvent mixtures.

This study highlights that variations in clinical outcome reporting can undermine the validation of NTCP models for RIA, stressing the need for a standardized and objective scoring system.

This study found that IL-1 blockers are effective for SURF and identified predictors of colchicine resistance, emphasizing the need for refined diagnostic criteria and personalized treatment due to the heterogeneity observed within SURF.

Among a Han Chinese cohort, this study found that a higher genetic risk score was linked to increased susceptibility to BPH, larger prostate size, reduced effectiveness of 5ARI treatment, and a higher risk of undergoing TURP.

This study suggests that human DSCCs may aid in hair follicle regeneration and reduce microinflammation, with potential applications in regenerative medicine evaluated through a new morphometric analysis.

This study highlights that stress and coping styles significantly influence the symptom severity of Indian women with PCOS, emphasizing a need for culturally appropriate interventions to improve quality of life.

In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.

In this study, researchers developed self-assembled skin models derived from hair follicle cells, offering an ethical and reliable alternative to animal testing and bovine collagen in dermatological research by providing functional dermal and epidermal layers for substance evaluation.

This study found that fasting insulin levels are associated with increased cardiovascular and metabolic risk factors in women with polycystic ovary syndrome.

This study found that improved testosterone measurement using LC-MS/MS in women with PCOS revealed a stronger correlation between hyperandrogenism and insulin resistance than previously detected.

This study found that women with PCOS had significantly elevated plasma levels of PAI-1, which correlated with insulin resistance and obesity.

Methylprednisolone treatment helps most alopecia areata patients, but young age, extensive hair loss, and low vitamin D can affect results.