research Faculty Opinions recommendation of De novo production of dermal papilla cells during the anagen phase of the hair cycle.
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180-210 / 1000+ results research Artificial neural networks algorithms for prediction of human hair loss related autoimmune disorder problem
This study evaluates a framework using neural networks and machine learning techniques to classify and detect Alopecia Areata from hair images, aiming for accurate differentiation between healthy hair and the condition.
research Mechanistic insights of desmopressin loaded elastic liposomes for transdermal delivery: HSPiP predictive parameters and instrumental based evidences
In this study, desmopressin-loaded elastic liposomes (ODEL1) showed improved permeation and drug deposition across rat skin by altering the skin's cohesive energies and causing reversible changes on its surface.
research Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies
This review suggests a shift toward genetically informed treatments for male pattern hair loss by integrating genetic insights and pharmacogenetic markers into therapeutic decision-making.
research Alopecia areata: Multivariate analysis for predicting its clinical course
This study reported an increase in allergic contact dermatitis cases linked to natural products, particularly propolis and marigold, with a higher incidence in women than men.
research CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung
In this study, CD4+CD25+FoxP3+ Regulatory T cells were found to reduce TGF-b1 induced lung fibrosis and fibrocyte accumulation in mice, partly by suppressing fibroblast growth factor 9.
research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1
This study found that IGF1, retinoic acid, and dexamethasone increase IGFBP-3 production in cultured human dermal papilla cells, potentially inhibiting IGF1 action on hair growth.
research Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis
This study found that progesterone significantly delayed epileptogenesis development in a mouse model, and its effects were inhibited by finasteride, highlighting the potential role of neurosteroids in modifying epilepsy progression.
research A computational approach to mechanistic and predictive toxicology of pesticides
This study investigated the modes of action of selected pesticides, suggesting that prochloraz and tebuconazole are linked to reproductive disorders via steroidogenesis disruption, while mancozeb involves inflammatory processes.
research Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review
This review discusses mechanisms of wound healing impairment in leptin-deficient murine models used for diabetic research, and reports no new clinical results; the authors emphasize the need for further study.
research UV light may induce hypertrichosis through production of PGE2
UV light might cause excessive hair growth by increasing PGE2 in the skin.
research Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis
This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.
research Transcriptome Analysis of Improved Wool Production in Skin-Specific Transgenic Sheep Overexpressing Ovine β-Catenin
This study suggests that β-catenin plays an important role in wool follicle development in transgenic sheep by enhancing the expression of keratin protein genes.
research Understanding host-graft crosstalk for predicting the outcome of stem cell transplantation
This study explored how high glucose concentrations impact mesenchymal stromal cell survival in diabetic environments, highlighting mitochondrial factors as potential targets for enhancing cell viability.
research A Novel In Vivo Active Pemphigus Model Targeting Desmoglein1 and Desmoglein3: A Tool Representing All Pemphigus Variants
This study developed and characterized new mouse models of Pemphigus that mimic different forms of the disease, but treatment with Methyl-Prednisolone showed only partial effectiveness.
research A brief report on PCOS: and its inducing model
This review discusses the use of experimental animal models to better understand the poorly understood mechanisms behind polycystic ovarian syndrome and reports no new clinical results.
research Dormant tumor cells in ret transgenic mouse melanoma model and their interaction with memory T cells
In this study, researchers observed that dormant TRP-2+ melanoma cells in bone marrow can interact with CD8+ T cells in tumor-bearing ret transgenic mice, potentially influencing immune responses.
research A Data-Driven Approach to Polycystic Ovary Syndrome Diagnosis: Evaluating Machine Learning Models
This study found that using machine learning models, particularly Random Forest with 93% accuracy and 86% sensitivity, can effectively predict PCOS by analyzing features like antral follicle count, hair growth, and skin pigmentation, offering a promising alternative to traditional diagnostic methods.
research DiZyme: The Ultimate Resource for Nanozyme Multiple Catalytic Activity Prediction
In this study, researchers introduced a machine learning approach to discover new nanozymes through the DiZyme platform, enabling the accurate prediction of multiple catalytic activities, and providing a comprehensive database and assistant resources for users.
research The Carnivore Follicular Integrity Framework (CFIF): An Evolutionary-Mechanistic Model of Hair Follicle Stability, Regenerative Peptide Biology (GHK-Cu), and Anti-Glycation Microvascular Protection
This theoretical research project proposes the Carnivore Follicular Integrity Framework, suggesting that animal-based diets may support hair follicle stability through various evolutionary and mechanistic pathways.
research Long-Term Survival of Type XVII Collagen Revertant Cells in an Animal Model of Revertant Cell Therapy
Revertant cell therapy shows promise for treating type XVII collagen deficiency, but better cell selection methods are needed.
research Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production
This research found that Leydig cells significantly rely on synthesizing omega-6 HUFAs to support male steroid hormone production, highlighting a new role for these fatty acids in the male reproductive system.
research Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model
This study demonstrated that allopregnanolone administration caused significant scratching in atopic dermatitis mice, and ethanol-induced scratching may be linked to increased brain allopregnanolone levels.
research Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model
This review synthesizes existing research on the multilayered defense system of the skin, highlighting how physical, chemical, immune, and microbial barriers work together to maintain skin health, with disruptions in one often leading to broader barrier dysfunctions.
research Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming
In this study, fibroblasts from long-term skin biopsy cultures retained their ability to reprogram into induced pluripotent stem cells after 16 months, despite undergoing transcriptional changes and decreased proliferation rates over successive generations.
research PROMETHEUS: Automating Deep Causal Research Integrating Text, Data and Models
This study introduces PROMETHEUS, a framework that organizes causal claims from scientific texts into navigable and persistent "causal atlases," enhancing research by highlighting localized evidence, agreement, and contradictions within complex data sets.
research In vitro strategies for mimicking dynamic cell–ECM reciprocity in 3D culture models
This review describes bioengineering strategies to mimic the natural cell microenvironment in vitro, emphasizing the novel approach of using cell-synthesized extracellular matrix as a scaffold for engineering functional 3D tissues, while highlighting the limitations of exogenous scaffolds in tissue engineering.
research The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis
In this study, researchers found no hypertrophy in axillary sweat glands of hyperhidrotic patients, with eccrine gland clear cells being the primary site of fluid transport and no evidence of apoeccrine glands.
research Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis
This study observed that K5Cre +/+ transgenic mice develop a distinct phenotype characterized by wavy hair, curly whiskers, and an increased rate of papilloma malignant transformation.
research Fish Cell Spheroids, a Promising In Vitro Model to Mimic In Vivo Research: A Review
This review highlighted that in an in vitro setting, 3D spheroid cultures of fish cells offer a promising alternative to traditional monolayer cultures, potentially advancing research in eco-toxicology, immunology, drug screening, and more by better mimicking in vivo conditions.