22 citations
,
December 1998 in “Dermatologic Surgery” This study found that preserving hair micrografts in an enriched storage medium for five hours significantly increased their survival rate compared to those stored in saline.
15 citations
,
December 2007 in “Dermatologic Therapy” This review discusses past hair transplantation techniques for androgenic alopecia and current research to improve results, but it reports no new clinical outcomes.
2 citations
,
April 2025 in “Cells” This study found that heat preconditioning of nanofat from mice did not improve tissue vascularization or integration in grafting, and actually reduced vascularization due to increased expression of anti-angiogenic factors, suggesting it is not beneficial for enhancing its vascularization properties.
30 citations
,
November 2020 in “Journal of Advanced Research” This study found that conditioned medium from keratinocytes improved the hair-inductive properties of cultured dermal papilla cells, suggesting potential for enhancing hair follicle regeneration.
320 citations
,
December 2018 in “Frontiers in Immunology” This review explores how preconditioning mesenchymal stromal cells can impact their secretome's therapeutic potential in regenerative medicine, emphasizing immunomodulatory and regenerative functions, but provides no new clinical results.
May 2025 in “Plastic & Reconstructive Surgery Global Open” In this proof-of-concept study, researchers found that hair grafts preserved in preconditioned autologous platelet-rich plasma with photothermal biostimulation and phosphate-buffered saline remained viable for eight hours before transplantation, outperforming saline solution and Ringer's lactate by two hours.
43 citations
,
June 2016 in “Clinics in Plastic Surgery” This article reviews technical aspects of using autologous fat transfer for facial rejuvenation and examines existing evidence for stem cell and platelet-rich plasma therapies in aesthetic practice, reporting no new results.
10 citations
,
January 2004 in “Dermatologic Surgery” This study found that storing hair follicle micrografts in HEPES-buffered DMEM with ACD inhibitors like aminoguanidine significantly increased hair shaft elongation compared to phosphate-buffered salt solution, suggesting improved viability for transplantation.
In this systematic review, the authors reported that both FUE and FUT hair transplant techniques induce oxidative stress and inflammation, impacting graft survival, but interventions like PRGF, CO2 laser, and dermal microtissues can enhance healing, reduce inflammation, and improve follicular survival.
December 2024 in “Journal of Clinical Medicine” This study found that wound bed perfusion strongly predicts skin graft viability by correlating with lower necrosis extension on both the scalp and lower limb, unlike perfusion of the wound margin and donor skin, which showed no significant correlation.
January 2016 in “Springer eBooks” New materials and methods could improve skin healing and reduce scarring.
139 citations
,
February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.
2 citations
,
May 2018 in “Expert opinion on orphan drugs” This review discusses Omenn syndrome, a form of severe combined immunodeficiency, highlighting its immunopathology and genetic defects without presenting new clinical results.
3 citations
,
January 2024 in “Cell Transplantation” This study reviews various factors affecting mesenchymal stem cell transplantation efficacy, including platelet concentrate composition, donor characteristics, and environmental influences, and examines strategies for optimizing outcomes through preconditioning and combined therapies in regenerative medicine.
5 citations
,
January 2023 in “Cell proliferation” This study reported that supplementing rat hair follicle stem cells with chick embryo extract enhanced their migration and proliferation, possibly promoting differentiation toward Schwann cells.
This study found that hypoxic preconditioning of nanofat from donor mice reduced its vascularization capacity in vivo, suggesting that this approach cannot currently enhance nanofat's regenerative potential.
May 2025 in “The Open Biomedical Engineering Journal” This review discusses the use of adipose tissue and platelet-rich plasma in tissue repair and regeneration, noting their promise in surgical outcomes but emphasizing the need for further research to optimize therapies.
7 citations
,
December 2022 in “Frontiers in Bioengineering and Biotechnology” This review discusses the role of extracellular vesicles as therapeutic agents for wound healing and highlights the need for further research into their clinical applications.
June 2026 in “Journal of Cutaneous and Aesthetic Surgery” This study examined five patients with cicatricial alopecia treated using the follicular unit extraction technique, finding an average graft survival rate of 64.2% and acceptable transection rates, despite the procedure's challenges compared to non-scarring alopecia.
31 citations
,
September 1999 in “Dermatologic Surgery” This study found that cooling hair grafts during transplantation did not significantly improve the survival or growth rates of hair follicles compared to room temperature storage.
2 citations
,
January 2016 in “Springer eBooks” This review discusses the potential of adipose-derived stem cells for regenerative medicine, highlighting their ability to differentiate, secrete factors, and modulate the immune response, but reports no new findings.
135 citations
,
December 2015 in “Expert Opinion on Biological Therapy” This review synthesizes recent research on exosomes, highlighting their role as key modulators in regenerative outcomes and suggesting they may offer advantages over stem cell-based therapies in process and regulation.
September 2024 in “Advanced Biomedical Research” In this study, chick embryo extract enhanced neuronal differentiation and trophic factor expression in rat hair follicle stem cells, suggesting potential improvements for stem cell therapies in neurodegenerative diseases.
1036 citations
,
August 2019 in “Cells” This article provides an overview of mesenchymal stem cells, highlighting their extraction methods, differentiation potential, and applications in regenerative medicine, but reports no new clinical findings.
269 citations
,
October 2017 in “International Journal of Molecular Sciences” This review examines the challenges of cell engraftment in regenerative medicine and discusses potential strategies to improve the efficacy of cell-based therapies, including cell-free regenerative approaches.
9 citations
,
May 2022 in “Frontiers in Cellular Neuroscience” Mesenchymal stromal cell therapies show promise for treating various diseases but need more research and standardization.
February 2025 in “Biochemistry” This review summarizes the potential therapeutic applications of stem cells in dermatology, emphasizing their role in restorative and regenerative treatments through injections, topical applications, and scaffolds, supported by advancements in laboratory processes and quality control.
June 2023 in “Plastic and Reconstructive Surgery – Global Open” This review found that exosome use in aesthetic plastic surgery shows promise in areas like skin rejuvenation and hair restoration, with laboratory studies indicating enhanced outcomes, but clinical evidence remains largely anecdotal, and no exosome-based products have FDA approval.
44 citations
,
April 2023 in “Genes & Diseases” This review discusses the paracrine function of mesenchymal stem cells in tissue regeneration and repair, focusing on secreted bioactive substances and their role under different microenvironments; it reports no new clinical results.
30 citations
,
May 2019 in “Medicinal Research Reviews” This review discusses molecular and cellular strategies to improve muscle and skin regeneration and reduce scarring after cleft lip repair, offering potential benefits for function and aesthetics.