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    Glossary Preclinical Studies

    laboratory and animal tests before human clinical trials

    Preclinical Studies, also known as Preclinical Research or Preclinical Testing, are a phase of research conducted before clinical trials in humans. These studies involve laboratory experiments and animal testing to evaluate the safety, efficacy, and biological activity of a new drug or treatment. The goal is to gather enough data to determine whether the treatment is safe and promising enough to move on to human trials.

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    1. Preclinical studies of a novel polyherbal phyto–complex hair growth promoting cream Asian pacific Journal of Tropical Biomedicine · 2012 · 16 citations
    2. The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines Wound Repair and Regeneration · 2024 · 11 citations
    3. Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health Evidence-based Complementary and Alternative Medicine · 2017 · 11 citations
    4. The Use of Stromal Vascular Fraction in the Treatment of Male Sexual Dysfunction: A Review of Preclinical and Clinical Studies Sexual medicine reviews · 2018 · 11 citations
    5. Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies Stem Cell Reviews and Reports · 2022 · 30 citations
    6. Therapeutic Effects of Alkaloids on Influenza: A Systematic Review and Meta-Analysis of Preclinical Studies International Journal of Molecular Sciences · 2025
    7. Topically used herbal products for the treatment of hair loss: preclinical and clinical studies Archives of Dermatological Research · 2017 · 25 citations
    8. Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review International Journal of Molecular Sciences · 2021 · 46 citations
    9. Synergistic effects of mesenchymal stem cells and their secretomes with scaffolds in burn wound healing: a systematic review and meta-analysis of preclinical studies Journal of Translational Medicine · 2025 · 16 citations
    10. Cell-derived exosome therapy for diabetic peripheral neuropathy: a preclinical animal studies systematic review and meta-analysis Stem Cell Research & Therapy · 2025 · 8 citations
    11. Exosome-driven treatments for hair regrowth in androgenetic alopecia: a systematic review of preclinical studies, clinical experiments, safety, and future prospects Molecular Biology Reports · 2026
    12. Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies Stem Cell Research & Therapy · 2020 · 15 citations
    13. Quercetin-Based Advanced Delivery Systems – From Multimodal Nano-theranostics to Microneedles: a Recent Update on Their Preclinical Studies International Journal of Nanomedicine · 2026
    14. Review on methods and mechanisms available for producing poly cystic ovary syndrome (PCOS) in animal models: experimental purpose (pre-clinical studies) World journal of pharmaceutical sciences · 2022
    15. 614 Humanized mouse model for hair follicle studies Journal of Investigative Dermatology · 2019
    16. Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened Clinical cancer research · 2011 · 63 citations
    17. New developments in the molecular treatment of ichthyosis: review of the literature Orphanet journal of rare diseases · 2022 · 21 citations
    18. Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities Journal of cosmetic dermatology · 2022 · 12 citations
    19. Imaging prostate cancer (PCa) with [<sup>99m</sup> Tc(CO)<sub>3</sub> ]finasteride dithiocarbamate Journal of labelled compounds & radiopharmaceuticals · 2018 · 4 citations
    20. Extracellular Vesicles for Androgenetic Alopecia: Current Evidence, Mechanisms, and Clinical Prospects DOAJ (DOAJ: Directory of Open Access Journals) · 2026
    21. ISID0197 - Quantitative analysis of hair loss in mice utilizing imageJ improves the efficacy evaluation of alopecia areata induction in the C3H/HeJ mouse model 2023
    22. The Evolution of Emerging Nanovesicle Technologies for Enhanced Delivery of Molecules into and across the Skin Pharmaceutics · 2024 · 1 citations
    23. Therapeutic Potential of Topical Metformin in Diabetic Wound Healing: Preclinical Mechanistic Insights Jurnal Kesehatan · 2026
    24. Omega Fatty Acids in Hair Loss Disorders: A Scoping Review of Preclinical and Clinical Evidence Journal of Cosmetic Dermatology · 2026
    25. Unraveling Translational Insights into Systemic Multi-Organ Toxicity of Cytosine Arabinoside (Ara-C): A Systematic Review of Preclinical Animal Evidence Current Issues in Molecular Biology · 2025
    26. In-vivo studies to determine Hair Growth Potential of Poly Herbal Medicated Hair Oil in Female Swiss Albino Mice Research journal of pharmacy and technology · 2023
    27. Alopecia: from clinic to preclinic and back Formuly farmacii · 2019 · 1 citations
    28. 3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa Dermatology · 2021 · 4 citations
    29. The microfollicle: a model of the human hair follicle for in vitro studies In Vitro Cellular & Developmental Biology - Animal · 2020 · 16 citations
    30. Hair Growth-Supporting and Follicle-Protective Potential of a Botanical-Based Supplement Ingredient: In Vitro, Ex Vivo, and Molecular Docking Studies Biomolecules · 2026