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The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

Fat cells in the skin help start healing and form important repair cells after injury.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

Blocking β-catenin in skin cells improves hair growth during wound healing.

PDRN helps repair tissue and improve wound healing with a high safety profile.

Targeting the skin's endocannabinoid system could help treat skin disorders.

The circadian clock influences the behavior and regeneration of stem cells in the body.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

MRL/MpJ mice's skin wounds heal with scars, unlike their ear wounds which can regenerate.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Lifestyle changes are the main treatment for PCOS, which is a complex condition requiring early management to reduce its health impacts.

The conclusion is that CD90 is not a specific marker for fibroblast subtypes and better methods are needed to identify them.

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

The document concludes that understanding hair follicles requires more research using computational methods and an integrative approach, considering the current limitations in hair treatment products.

Researchers developed a method to grow hair follicle cells for transplantation using a special chip.

DHT stops hair regrowth in mice, similar to human hair loss.

Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.

Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.

Surgery to lower high testosterone in postmenopausal women with certain ovarian tumors doesn't significantly affect their metabolism.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

Hormones and genes affect hair growth and male baldness.

ACBP is essential for healthy skin and fur by maintaining the skin's barrier function.

Fat tissue extract may help treat vitiligo by reducing cell stress and promoting skin repair.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Adipose-derived stem cells show potential for skin rejuvenation and wound healing but require more research to overcome challenges and ensure safety.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Active oxygen species might be involved in skin tumor growth, but their exact role is unclear.

Using skin stem cells and certain molecules might lead to scar-free skin healing.