November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that a skincare product effectively prevented and reduced pollen allergen accumulation in hair follicle models by forming a protective film and exhibiting strong cleansing properties, suggesting its potential to protect skin from environmental elements that can lead to irritation and allergic reactions.
November 2022 in “Journal of Investigative Dermatology” This study identified a novel LZTR1 mutation associated with hybrid schwannoma and neurofibroma in a patient with schwannomatosis, but not all cases of hybrid tumors are linked to this condition.
November 2022 in “Journal of Investigative Dermatology” This study suggests that applying a botanical extract targeting mechanosensory receptors improved well-being, oxytocin levels, and skin appearance in participants, unlike a placebo.
November 2022 in “Journal of Investigative Dermatology” This review summarizes 57 case reports and series, noting that ultrasound is a useful, non-invasive tool to visualize subcutaneous nodules in conditions like sarcoidosis, granuloma annulare, and panniculitis, facilitating diagnosis and treatment without ionizing radiation.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that applying ivermectin 1% cream significantly improved both visible symptoms like erythema and invisible symptoms such as stinging, burning, and dryness in rosacea patients over a period of at least 16 weeks.
November 2022 in “Journal of Investigative Dermatology” This study found that the cytoplasmic dynein component Dynlt3 is essential for effective melanosome transport and transfer in mouse melanocytes, linking melanosome positioning and acidity to the Wnt/β-catenin signaling pathway.
September 2022 in “Journal of The American Academy of Dermatology” This case report describes a 58-year-old woman with telogen effluvium linked to COVID-19 whose hair loss symptoms greatly improved after using a specific hair care routine for 30 days.
September 2022 in “Journal of The American Academy of Dermatology” This study found that baricitinib was effective in regrowing eyebrow and eyelash hair in patients with severe alopecia areata, with similar improvements observed in both clinician-reported and patient-reported measures.
September 2022 in “Journal of the American Academy of Dermatology” This study observed that tofacitinib therapy over about 16 weeks had a positive effect in children with alopecia areata, reducing the SALT index significantly in some patients.
September 2022 in “Journal of The American Academy of Dermatology” This review summarizes existing literature on COVID-19-associated alopecia, finding that androgenic alopecia may increase COVID-19 risk, while telogen effluvium often follows infection.
September 2022 in “Journal of The American Academy of Dermatology” This study found that PRP is most commonly used for treating androgenetic alopecia and facial rejuvenation, with no serious adverse events reported among participants.
September 2022 in “Journal of the American Academy of Dermatology” This study compares the prevalence of vitamin D deficiency in patients with lichen planopilaris/frontal fibrosing alopecia to the general US population, highlighting an area not well-explored in existing research.
August 2022 in “JAAD case reports” This case report describes a 36-year-old woman with hidradenitis suppurativa whose condition progressed to rapidly fatal squamous cell carcinoma, highlighting the potential for aggressive tumor development linked to specific protein markers.
July 2022 in “Journal of Investigative Dermatology” This study suggests that interleukin-15 plays a complex role in alopecia areata, potentially contributing to immune infiltration while also protecting against hair follicle immune privilege collapse and promoting hair growth.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrated that Tet2 and Tet3 enzymes are crucial for controlling gene expression related to hair differentiation in mice, suggesting DNA demethylation could be a new method for managing hair growth.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study indicates that MPZL3 negatively regulates sebaceous gland size in mice by controlling sebocyte proliferation, with implications for disorders like acne and psoriasis.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that carefully engineered hydrogels and asymmetric morphogen gradients facilitated the formation of anatomically relevant skin organoids from iPSC-derived EBs, improving pigmentation and hair follicle generation.
July 2022 in “Journal of Investigative Dermatology” This study found that DPP4 inhibition in mice can enhance hair follicle activation and regeneration, suggesting a potential therapeutic strategy for improving hair growth and wound-induced hair follicle neogenesis.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that particulate matter can induce inflammation in human outer root sheath cells, potentially affecting hair growth, through oxidative stress-dependent MAPK and JAK-STAT signaling pathways.
July 2022 in “Journal of Investigative Dermatology” This study found that Substance P increased mitochondrial activity and biogenesis markers in cultured human scalp hair follicles, suggesting a novel link between stress-related neuropeptide signaling and hair follicle mitochondrial responses.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that Myelin Protein Zero-like 3 plays a crucial role in hair follicle cycling by regulating anagen and catagen phases, mediated through mitochondrial signaling mechanisms in both human and murine hair follicles.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that impaired Nrf2 signaling and its relationship with keratin 16 may contribute to follicular hyperkeratinization and occlusion in hidradenitis suppurativa, opening new therapeutic avenues.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that combining Silybum marianum extract, Manganese PCA, and Lespedeza capitata extract may help improve hair growth and anchorage by targeting specific signaling pathways in human dermal papilla cells.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting mTORC1 activity with rapamycin significantly increased melanin production and extended hair growth phase in human hair follicles, suggesting potential for managing hair growth and pigmentation disorders.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that TSPyV T antigens can disrupt normal cell differentiation and proliferation in hair follicles and interfollicular epidermis, possibly contributing to trichodysplasia spinulosa pathology.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that locally administering thymic stromal lymphopoietin (TSLP) promotes hair growth by stimulating hair follicle cell proliferation during both normal conditions and after skin injury in mice.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that apocynin restored COL17A1 expression in human keratinocytes and reduced UVB-induced cellular senescence, DNA damage, and cell cycle arrest.
July 2022 in “Journal of Investigative Dermatology” This study suggests that high platelet concentrations in PRP may not be necessary for hair growth in androgenetic alopecia, and certain growth factors might negatively impact clinical outcomes.
July 2022 in “Journal of Investigative Dermatology” This study developed a method to quantify hormones in skin secretions and found that hormonal composition varies by sex and anatomical site.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This source reviews current research on using exosomes for treating alopecia and finds promising preclinical evidence, particularly with exosomes from dermal papilla and adipose-derived stem cells. However, it highlights significant gaps in clinical translation regarding safety, delivery, and mechanisms, suggesting more rigorous studies are needed.