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Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Oxidative stress contributes to hair graying and loss as we age.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Stress can worsen skin conditions by affecting hormone levels and immune response.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

New alopecia treatments aim for better results and fewer side effects.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

*Acorus calamus* has many medicinal benefits but needs more safety research.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Plant-based ingredients are effective and safe for modern skincare products.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Skin and hair can regenerate after injury due to changes in gene activity, with potential links to how cancer spreads. Future research should focus on how new hair follicles form and the processes that trigger their creation.

Caffeine applied to the scalp can protect hair follicles from UV damage.

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.

Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

Hair loss in cancer patients can be related to the cancer itself, treatment, or other conditions, and understanding it is important for diagnosis and patient care.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.