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The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.

Insulin resistance is linked to PCOS and can lead to other health issues, but treatments like metformin can help manage symptoms.

Fat-related cells are important for initiating hair growth.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

PGD2 stops hair growth and is higher in bald men with AGA.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Oxidative stress contributes to hair graying and loss as we age.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Treatments for permanent hair loss from scarring aim to stop further loss, not regrow hair, and vary by condition, with partial success common.

Fatty acid transport protein 4 is essential for skin and hair development.

Skin fat helps with body temperature control and has other active roles in health.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

The document concludes that proper diagnosis and FDA-approved treatments for different types of hair loss exist, but treatments for severe cases often fail and future improvements may focus on hair follicle stem cells.

The circadian clock influences the behavior and regeneration of stem cells in the body.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.