July 2018 in “Elsevier eBooks” This study highlights lichen planopilaris as a form of scarring hair loss with symptoms like shedding and itching, and notes successful treatment options such as topical and oral antiinflammatory medications to preserve hair follicles by early intervention.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that cPPARγ and dnPPARγ isoforms are differentially expressed in healthy human skin, suggesting that PPARγ modulators may have compartment-specific effects depending on isoform presence.
March 2024 in “World Academy of Sciences Journal” This narrative review explores how exercise might help maintain skin homeostasis disrupted by protein deficiency, potentially by promoting processes like increased collagen synthesis and stimulating anti-inflammatory effects, though the exact mechanisms are not entirely understood.
44 citations
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November 2011 in “The Journal of Dermatology” This review discusses recent advancements in the management and diagnosis of primary cicatricial alopecias but reports no new clinical results; emerging insights suggest sebaceous gland dysfunction may play a role in their etiopathogenesis.
46 citations
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April 2008 in “Archives of Dermatological Research” This study found that substance P may be involved in the pathogenesis of acne by increasing the expression of certain cytokines and receptors in cultured sebocytes.
45 citations
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February 2019 in “Journal of Affective Disorders” This study found that 12 weeks of melatonin supplementation improved mental health and metabolic parameters in women with polycystic ovary syndrome compared to a placebo.
23 citations
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October 2018 in “Australasian Journal of Dermatology” This review highlights that frontal fibrosing alopecia’s increasing incidence may involve immune, genetic, hormonal, and environmental factors, yet its pathogenesis remains complex and not fully understood.
2 citations
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January 2015 in “Springer eBooks” Early diagnosis and aggressive treatment are crucial for Cicatricial Alopecia, and treatment effectiveness varies among patients.
November 2015 in “European Journal of Inflammation” This review discusses the potential pathogenic mechanisms of cicatricial alopecia and emphasizes the need for further research on treatment methods, but it reports no new clinical findings.
238 citations
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March 2013 in “Development” This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.
6 citations
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April 2022 in “Frontiers in cell and developmental biology” This study identified differentially expressed proteins and pathways potentially involved in wool bending in Zhongwei goats, with specific genes like COL6A1 and CRNN emerging as important candidates in this process.
2 citations
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February 2025 in “International Journal of Molecular Sciences” This study identified key proteins, such as Sfrp1 and Ppard, involved in the complex and dynamic regulation of yak hair follicle growth and degeneration across different stages, offering insights into yaks' adaptation to highland environments.
This study found that protein hydrolysates from mealworms, especially those derived using flavourzyme, significantly enhance adipogenic differentiation in 3T3-L1 preadipocytes, suggesting their potential as sustainable ingredients for glycemic control, skin health, and tissue regeneration products.
408 citations
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January 2017 in “Science” This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.
77 citations
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March 2014 in “Cold Spring Harbor Perspectives in Medicine” This research abstract provides no results, focusing on the equal contributions of the authors in the field of molecular, cellular, and developmental biology from Yale University.
This study found that periodic red light exposure in aged mice increased histone acetylation and activated metabolic processes in keratinocytes, mitigating cellular aging through enhanced fatty acid oxidation and altered gene expression related to lipid metabolism.
This study found that periodic red light exposure increased histone acetylation and activated metabolic processes in aged mice, leading to enhanced fatty acid oxidation and the mitigation of cellular aging by influencing gene expression and metabolic regulation.
1 citations
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March 2025 in “Journal of Investigative Dermatology” Metabolic issues may trigger lymphocytic cicatricial alopecia, and treatments targeting these issues could help.
March 2025 in “International Journal of Molecular Sciences” This study analyzed proteomic changes in Jiangnan cashmere goats' secondary hair follicles and found that the PLIN2 gene significantly impacts hair follicle growth cycles by affecting dermal papilla cell proliferation, offering insights into breeding strategies to enhance cashmere yield.
August 2023 in “Journal of Dermatological Science” A specific RNA molecule blocks hair growth by affecting a protein related to hair loss conditions.
October 2023 in “International journal of molecular sciences” In this study, researchers analyzed the skin proteome of Alpine Merino sheep to identify proteins and pathways related to wool fiber diameter, finding that cyclic adenosine monophosphate and certain signaling pathways may play a role in this trait.
April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, periodic exposure to red light in aged mice led to increased histone acetylation and activated mitochondrial fatty acid oxidation, which collectively mitigated cellular aging by modulating metabolism, inflammation, and gene expression.
The researchers reported that PPARβ/δ may influence the yak hair follicle cycle by modulating lipid metabolism in dermal papilla cells, with varying expression during different hair growth phases, affecting both lipid content and cell proliferation.
1 citations
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May 2022 in “Frontiers in Pharmacology” This study found that astilbin downregulates effector CD4+ T cell activities through the CYP1B1/ROS/PPARγ pathway, suggesting its potential use in treating inflammation.
December 2024 in “Frontiers in Pharmacology” In this study, human cell models of hair follicles showed that araliadiol, a plant-derived polyacetylene compound, promotes hair growth through the p38/PPAR-γ signaling pathway, suggesting its potential as a new drug candidate for alopecia treatment.
13 citations
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January 2020 in “Scientific Reports” This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.
2 citations
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August 2020 in “Scientific reports” This study identified genes potentially involved in the development and differentiation of skin appendages in Atelerix albiventris, noting significant enrichment of immune-related genes in hair-type tissues.
17 citations
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February 2018 in “Journal of Investigative Dermatology” This study found that the PPAR-γ modulator N-acetyl-GED may enhance mitochondrial function in human hair follicles, particularly in outer root sheath keratinocytes.
27 citations
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February 2020 in “EMBO Reports” This study concluded that MEX3A is critical for maintaining Lgr5+ intestinal stem cells by regulating the PPARγ pathway, impacting intestinal homeostasis during postnatal development in mice.
21 citations
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November 2022 in “Frontiers in immunology” This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.