136 citations
,
September 2019 in “Journal of Clinical Investigation” This study found that mature dermal adipocytes have high plasticity, undergoing dedifferentiation and redifferentiation, which plays a significant role in hair cycling and wound healing.
45 citations
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May 2022 in “Biomedicines” This review discusses using human follicular fluid in metabolomic analysis as a diagnostic tool and predictor of success in assisted reproductive technology for PCOS patients, reporting no new results.
31 citations
,
July 2021 in “ImmunoTargets and therapy” This review compiles current evidence on the molecular mechanisms, etiologies, and targeted immunotherapies for alopecia areata and reports no new experimental results, emphasizing the need for further research to manage the disease.
26 citations
,
December 2020 in “International Journal of Molecular Sciences” This review explores current and emerging treatments for polycystic ovary syndrome, focusing on managing hyperandrogenism and cardiometabolic risk, but reports no new clinical results.
24 citations
,
April 2008 in “Fertility and sterility” In this study, pioglitazone treatment in insulin-resistant PCOS patients decreased relative 5alpha-reductase activity without significantly affecting cortisol levels or urinary cortisol excretion.
20 citations
,
March 2021 in “Drug design, development and therapy” This review summarizes the pharmacology, mechanisms, and clinical efficacy of topical immunotherapy for alopecia areata but reports no new clinical results.
15 citations
,
December 2021 in “Pharmaceutics” This systematic review identified robust biomarkers associated with hidradenitis suppurativa and confirmed potential drugs for repurposing, highlighting key pathogenetic pathways and their links to comorbid disorders.
12 citations
,
October 2023 in “Journal of Mind and Medical Sciences” This source presents a comprehensive review of the literature on diabetes, highlighting the complex factors involved in its development and the importance of prevention, early diagnosis, and a multi-faceted treatment approach for effective management.
12 citations
,
May 2021 in “Clinical Interventions in Aging” This study found that men with androgenetic alopecia have different scalp biophysical characteristics in androgen-sensitive areas compared to non-sensitive areas and healthy controls.
10 citations
,
August 2022 in “International Journal of Molecular Sciences” This review discusses mechanisms of wound healing impairment in leptin-deficient murine models used for diabetic research, and reports no new clinical results; the authors emphasize the need for further study.
9 citations
,
April 2024 in “Metabolites” This study reviews the current research on the metabolomic profile and antimicrobial properties of the Cannabis plant, highlighting its effective antibacterial activity against multidrug-resistant bacteria while noting a lack of studies on its impact on plant and aquatic pathogens, emphasizing potential agricultural benefits.
8 citations
,
May 2025 in “Pharmaceuticals” This article reviews 27 small-molecule drugs approved by the FDA in 2024, noting that among them, eight "first-in-class" drugs with breakthrough therapy status show distinct mechanisms and substantial efficacy improvements in various conditions like cancer and chronic diseases.
8 citations
,
July 2021 in “Patient Preference and Adherence” This review discusses how alopecia impacts patients' quality of life and evaluates the use and limitations of HRQoL questionnaires without reporting new clinical results.
5 citations
,
November 2023 in “Journal of Investigative Dermatology” People with primary cicatricial alopecia have a higher risk of heart disease and stroke.
5 citations
,
September 2021 in “Clinical case reports” This case report documents the first known instance of Graham‐Little Piccardi Lassueur Syndrome in Saudi Arabia, observed in an adult dark-skinned male.
4 citations
,
December 2017 in “InTech eBooks” This review discusses the complexity and varied symptoms of polycystic ovary syndrome and emphasizes lifestyle changes and insulin-sensitizing agents as effective management strategies, but reports no new clinical results.
1 citations
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April 2025 in “Acta Dermato Venereologica” In this study, a retrospective analysis at Erasmus University Medical Center found that methotrexate and cyclosporine A may be most effective for lichen planopilaris and cyclosporine A and retinoids for frontal fibrosing alopecia, although side effects were a concern.
June 2026 in “Dermatology” In this study, frontal fibrosing alopecia showed a higher cumulative remission rate compared to lichen planopilaris, despite similar timeframes and relapse rates between the two conditions.
May 2026 in “International Journal of Molecular Sciences” This review highlights emerging evidence that chemotherapy-induced alopecia may be driven by immune mechanisms similar to alopecia areata, involving hair follicle immune privilege collapse, and evaluates Janus kinase inhibitors as potential treatments, while cautioning about their immunosuppressive risks in cancer patients.
November 2025 in “BMC Genomics” This study found that the systemic wrinkled skin phenotype in Xiang pigs involves gene expression changes and genetic variations associated with oxidative stress and extracellular matrix components, resembling features seen in Shar-Pei dogs.
October 2025 in “International Journal of Dermatology” Lasheras-Pérez et al. reported that JAK3 and TYK2 proteins are activated in certain forms of primary cicatricial alopecia, suggesting the JAK/TYK/STAT pathway as a potential therapeutic target for these conditions.
August 2025 in “Frontiers in Immunology” This study found that patients with primary cicatricial alopecia are at higher risk of developing various comorbidities, including systemic lupus erythematosus, hypothyroidism, and dermatological conditions, compared to controls.
August 2025 in “Cosmetics” This review discusses the possible link between cosmeceuticals and frontal fibrosing alopecia but reports no conclusive findings; the authors stress further research on environmental triggers is needed.
October 2024 in “Our Dermatology Online” This study highlights a close link between metabolic syndrome, characterized by conditions like obesity and hypertension, and various inflammatory skin diseases, suggesting that mitochondrial dysfunction plays a key role in their pathogenesis and could be a target for new therapies.
March 2024 in “Journal of Investigative Dermatology” This study found that patients with primary cicatricial alopecia had an 18% higher risk of developing cardiovascular diseases compared to control subjects, with certain subtypes showing a more pronounced increase.
September 2023 in “International journal of women’s dermatology” This study found mixed evidence linking traction hairstyles, previous pregnancies, chemical hair relaxers, and several comorbidities to an increased risk of central centrifugal cicatricial alopecia in Black women.
May 2023 in “Journal of Clinical Medicine” This review article reports recent advancements in understanding, diagnosing, and treating various hair loss conditions, like androgenetic alopecia and alopecia areata, including their genetic factors and new therapeutic options, while also examining the impact of COVID-19 on hair loss.
More research is needed to confirm PRP's effectiveness for scarring alopecia.
9 citations
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August 2024 in “Frontiers in Pharmacology” This review evaluates the potential of natural products and medicinal plants for myocardial infarction treatment, highlighting their therapeutic promise and mechanisms such as reducing oxidative stress and inflammation, but reports no new clinical results.
June 2026 in “International Journal of Molecular Sciences” This review synthesizes current evidence on the Warburg effect in anaplastic thyroid carcinoma and discusses potential therapeutic targets, but reports no new clinical results.