research Abstracts
New treatments and diagnostic methods for various animal skin conditions showed promising results.
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research A New Label-Free Screen for Steroid 5α-Reductase Inhibitors Using LC-MS
Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.
research Polycystic Ovary Syndrome (PCOS): An Inflammatory, Systemic, Lifestyle Endocrinopathy
PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.
research Targets to Treat Androgen Excess in Polycystic Ovary Syndrome
The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.
research Roles of Steroid Sulfatase in Brain and Other Tissues
Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.
research Topical L-Thyroxine: The Cinderella Among Hormones Waiting to Dance on the Floor of Dermatological Therapy?
Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
research Can Extra-Adrenal Cortisol Secretion Occur in an Adrenalectomized Patient?
A patient produced cortisol after adrenalectomy, possibly due to residual tissue or other body parts making steroids.
research Steroid 5α-Reductase 2 Deficiency Leads to Reduced Dominance-Related and Impulse-Control Behaviors
Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.
research Sulfotransferases, Sulfatases, and Formylglycine-Generating Enzymes: A Sulfation Fascination
The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.
research Cutaneous Toxicities From Transplantation-Related Medications
Skin problems from transplant drugs are common and need careful management in organ transplant patients.
research Alopecia Areata Universalis After Phenobarbital-Induced Anticonvulsant Hypersensitivity Syndrome
A 3-year-old boy lost all his hair due to a rare reaction to phenobarbital, but it grew back after steroid treatment.
research Clinical Impact of Molecular Diagnostics in Endocrinology
Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.
research Frontal Fibrosing Alopecia
Frontal fibrosing alopecia causes hairline recession and eyebrow loss in postmenopausal women.
research Hormonal and Reproductive Factors and Risk of Upper Gastrointestinal Cancers in Men: A Prospective Cohort Study Within the UK Biobank
Men with frontal male pattern baldness may have a higher risk of gastric cancer.
research Ovine Placental Steroid Synthesis and Metabolism in Late Gestation
Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.
research Androgen Antagonists in Androgen Target Tissues
Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.
research Regulatory Effects of Thai Rice By-Product Extracts from Oryza Sativa L. Cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition
BB4CMU rice bran oil may help treat hair loss and gray hair.
research Steroid Responsive Mononeuritis Multiplex in the Cronkhite-Canada Syndrome
Steroid treatment improved both gut and nerve symptoms in a man with Cronkhite–Canada syndrome.
research Small Molecule Wnt Pathway Inhibitor (SM04755) as a Potential Topical Psoriasis Treatment
SM04755 may be an effective topical treatment for psoriasis.
research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition
Finasteride effectively blocks rat enzymes, but with varying methods and strength.
research Acne in Dark Skin: Prevalence, Presentation, and Treatment
Acne in dark skin is influenced by environmental factors and can lead to hyperpigmentation, with various treatment options available.
research Comparison of High-Dose Corticosteroid Pulse Therapy and Combination Therapy Using Oral Cyclosporine with Low-Dose Corticosteroid in Severe Alopecia Areata
Corticosteroid pulse therapy is more effective for severe alopecia areata than combination therapy.
research Cyclosporine-Induced Gingival Hyperplasia in a Patient With Lichen Planopilaris: Misfortunes Never Come Singly
A patient's gum problems worsened after using cyclosporine for a scalp condition, but improved with a lower dose.
research Metabolic Study of Androsta-1,4,6-Triene-3,17-Dione in Horses Using Liquid Chromatography/High Resolution Mass Spectrometry
The study found that urine metabolites M1b or M4 are the best indicators of ATD use in horses, with detection possible up to 77 hours in urine and 28 hours in blood.
research Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model
A natural steroid in the body may protect against eye damage in glaucoma.
research The 1,25-Dihydroxyvitamin D3-Independent Actions of the Vitamin D Receptor in Skin
The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.
research Follicular and Scarring Disorders in Skin of Color: Presentation and Management
The conclusion is that better understanding and more research are needed to effectively manage follicular and scarring disorders in skin of color, with an emphasis on patient education and cultural awareness.
research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression
5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.
research Quality Control of the Flavosterol Emulgel for Androgenic Alopecia Prevention and Treatment
The "Flavosterol" emulgel meets quality standards for treating hair loss.
research Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways
Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.