March 2025 in “Asian Journal of Beauty and Cosmetology” This study found that microspicule cosmetics with low-molecular-weight peptide complexes significantly improved skin whitening, pore condition, and skin barrier function over four weeks compared to a non-microspicule formulation.
4 citations
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August 2022 in “Lasers in medical science” In this study, both 1565-nm non-ablative fractional laser and long-pulsed 1064-nm Nd:YAG laser effectively reduced enlarged facial pores, with no significant difference in efficacy and minimal side effects, though the Nd:YAG laser had less severe side effects.
In this study, women in their 40s with hair loss showed significant improvements in hair properties such as pore density and hair thickness when treated with a caffeine-based scalp ampoule and Microneedle Therapy System, compared to a caffeine-free control.
This study from years of treating hair loss in Japan reported various treatment outcomes: some patients showed improvement with manual treatment alone, others with added finasteride, some did not respond to either, and some maintained benefits even after stopping finasteride.
December 2023 in “Gugje bogeon mi-yong haghoeji” In this study, researchers observed that aroma oil-enhanced scalp scaling significantly improved scalp conditions over 8 weeks, marked by increased water and oil content, reduced keratin and surface value, and higher satisfaction in hair-related outcomes compared to the control group.
June 2023 in “Hanguk ingeurie hakoeji” This study found that consuming a fermented protein mixture for 60 days may increase hair density in healthy adults, although it did not significantly change other scalp or hair conditions like thickness, pore condition, or blood vessel exposure.
June 2026 in “Frontiers in Physiology” In this study, a topical cream containing 3% lactic acid ferment lysate (VHProbi ® MixP) was found to significantly reduce sebum, porphyrin levels, and pore size, while increasing hydration and improving skin texture in participants with oily skin over a 60-day period.
5 citations
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January 2023 in “Journal of Cosmetic Dermatology” This study found that microbotox, especially when injected intradermally, effectively reduces enlarged facial pores with higher patient satisfaction and longer-lasting results compared to its topical application after microneedling.
13 citations
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September 2011 in “American Journal of Clinical Dermatology” This review describes the dermatological uses of the contraceptive ethinylestradiol/chlormadinone acetate for conditions linked to high androgen levels and reports no new clinical results.
4 citations
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June 2024 in “Journal of Cosmetic Dermatology” In this study, fractional radiofrequency treatment was found to be effective, safe, and well-tolerated for patients with erythematotelangiectatic rosacea, with high satisfaction rates.
2 citations
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June 2024 in “Regenerative Therapy” In this study, ozone treatment was shown to increase the concentration of growth factors like EGF and TGF-β in PRP in vitro, suggesting that oxygen-rich PRP injections may provide an effective method for facial rejuvenation.
October 2025 in “Journal of Cosmetic Dermatology” This study found that the AOPT-MTL mode is an effective and safe treatment option for nasal blackheads in Asians, indicating potential for widespread clinical use.
55 citations
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April 2018 in “Advanced Healthcare Materials” This review discusses recent advances in scarless wound healing, focusing on strategies to create pro-regenerative scaffolds for repairing damaged skin, and reports no new clinical results.
60 citations
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June 2019 in “Ageing Research Reviews” This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.
8 citations
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February 2022 in “Molecules” This study found that Asparagus racemosus root extract significantly reduced facial sebum production and pore size in male volunteers, suggesting potential application as an anti-sebum ingredient in cosmetics.
1 citations
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January 2024 in “Journal of Cosmetic Dermatology” In this study, JAUN soap was found to improve skin conditions, such as moisture, elasticity, and cleansing effectiveness, without adverse reactions, suggesting its potential as a safe and effective ingredient for functional cosmetics.
This study reviewed the potential adverse effects of coconut oil on hair and found that its high protein content and greasy texture can cause clogged pores, inflammation, and hair damage if overused, highlighting the importance of careful application to prevent these issues.
6 citations
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July 2024 in “Journal of Cosmetic Dermatology” In this study, researchers found that a composition containing mannose-6-phosphate significantly reduced the total skin pore area by 24% in women after 56 days and by 30.2% in men after 7 days, suggesting its effectiveness in improving pore appearance by targeting dermal and epidermal modifications.
October 2024 in “Applied Sciences” In this study, tubular 3D bioprinted structures made from sodium alginate and gelatin, containing NIH/3T3 fibroblast cells, demonstrated the ability for cell growth and network formation over 6 weeks, although structural tensile strength decreased with cell growth and polymer degradation.
70 citations
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February 2021 in “International Journal of Molecular Sciences” This review provides an overview of current research on AD-MSCs, PRP, and biomaterials, highlighting their safety and efficacy in treating soft tissue defects and chronic wounds without major side effects.
7 citations
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December 2024 in “International Journal of Pharmaceutics” In this study, researchers developed a new method for producing dissolving microneedle array patches containing mesoporous silica nanoparticles, successfully confirming nanoparticle deposition and release in both ex vivo and in vivo models.
December 2023 in “Polish Journal of Chemical Technology” This study found that Ajuga reptans leaf and root extracts, when incorporated into cosmetic products, improved skin hydration, elasticity, pore size, hyperpigmentation, and wrinkle depth.
17 citations
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August 2010 in “International Journal of Cosmetic Science” This study found that a cosmetic formula containing 2% Orthosiphon stamineus leaf extract significantly reduced skin oiliness and pore size, showing better results than a formula with 1% zinc gluconate.
4 citations
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December 2021 in “Journal of Pharmacopuncture” This study reports that the microneedle therapy system has demonstrated significant effects on acne, acne scars, and hair loss treatment without serious side effects in Korean studies over the past decade.
5 citations
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August 2022 in “Mediators of Inflammation” This study found that combining pulsed dye laser with pingyangmycin improved treatment efficacy, scar repair, skin condition, and patient satisfaction in treating post-acne hyperplastic scars, compared to laser alone, without increasing adverse reactions.
August 2026 in “Journal of Cosmetic Dermatology” This study found that Plinest injections improved skin hydration and elasticity in the face, neck, and décolleté and were well-tolerated, with high patient satisfaction over a 4-month follow-up.
March 2026 in “International Journal of Homoeopathic Sciences” This case report describes the improvement of papulo-pustular acne in a 27-year-old woman through individualized homoeopathic treatment with Kalium bromatum, placebo, and lifestyle advice, highlighting its potential usefulness in acne management.
108 citations
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December 2003 in “Lasers in surgery and medicine” This study found that combining near-infrared laser phototherapy with indocyanine green application may improve acne vulgaris by reducing active lesions and inflammation without side effects.
42 citations
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December 2014 in “Clinical, cosmetic and investigational dermatology” This review indicates that microneedle bipolar RF and fractional bipolar RF treatments offer significant improvement in acne scarring, with optimal results observed about three months after treatment.
1 citations
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January 2009 In this case report, a 25-year-old man with nevus comedonicus showed no improvement from keratolytics and topical tretinoin, but had success with surgical excision of the lesions.