18 citations
,
September 1990 in “Veterinary Dermatology” This study in SPF lambs found that primary and secondary orf virus infections trigger similar skin responses, but the primary infection caused a more severe and prolonged reaction.
1 citations
,
December 2023 in “PubMed” This study on rats found that combining platelet-rich plasma with stromal vascular fraction cells helped accelerate burn wound healing by affecting inflammatory cell counts and COX-2 expression, with differing impacts observed between acute and sub-acute phases of healing.
2 citations
,
July 1982 in “British Journal of Dermatology” This study reports that retinol acetate inhibited the pro-oxidant effects of benoxaprofen on polymorphonuclear leucocytes in vitro.
138 citations
,
June 2019 in “Stem Cells and Development” This review explores the potential of periodontal ligament stem cells for regenerative therapy in periodontium, despite challenges due to their rarity, and reports no clinical results.
86 citations
,
April 2016 in “Nature Communications” This study suggests that Notch1 acts as a key signal in skin epithelium, promoting immune cell recruitment and aiding in normal skin repair after damage.
24 citations
,
January 2012 in “Journal of Cellular Biochemistry” This study found that C-reactive protein may enhance monocyte adhesion to endothelial cells through NOX-mediated oxidative stress, suggesting a potential mechanism for atherogenesis.
18 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.
August 2018 in “Journal of The American Academy of Dermatology” A 90-year-old woman's hand lesion was a rare, aggressive skin cancer treated successfully with surgery.
38 citations
,
August 2012 in “Biochemical and biophysical research communications” This study found that leukocytes and beard hair follicle cells have an endogenous circadian clock, with PER1 and PER3 expression possibly serving as biomarkers for assessing individual biological clock traits.
23 citations
,
September 2015 in “PLOS ONE” This study found that mesenchymal stem cells, especially when injected intradermally, significantly accelerated wound healing in rats compared to chitosan treatment.
8 citations
,
September 2017 in “Journal of Natural Medicines” This study reported that the n-butanol fraction of Perilla frutescens extract, particularly rosmarinic acid, showed potential for hair regrowth and anti-androgenic activity in male mice, suggesting it as a possible treatment for androgenetic alopecia.
6 citations
,
September 2009 in “European journal of histochemistry” This study found that CD90+ stem cells with fibroblast-like morphology are present in the lower part of the anagen hair follicle in dogs.
February 2026 in “Frontiers in Immunology” This study found that administering human amniotic mesenchymal stem cells (hAMSCs) in a mouse model of psoriasis improved skin lesions and reduced inflammation-related markers, suggesting potential therapeutic benefit and safety for treating psoriasis, and identified specific gene targets involved in the treatment's mechanism.
24 citations
,
September 2005 in “Journal of Cellular Biochemistry” This study found that all-trans and 9-cis retinoic acids increase steroid sulfatase activity in HL60 cells through mechanisms involving RARα/RXR heterodimers and multiple signaling pathways.
6 citations
,
March 2021 in “Cytotechnology” This review examines recent findings on COVID-19 pneumonia treatment using mesenchymal stem cells and reports no new clinical results; the authors highlight MSCs' potential due to their immunomodulatory and tissue-regenerative properties.
252 citations
,
April 2009 in “Seminars in Cell & Developmental Biology” This review discusses the complex role of the immune system in tissue repair and regeneration, highlighting its positive and negative influences but reports no new clinical findings.
55 citations
,
November 2004 in “Expert opinion on drug safety” This review describes the variety of mucocutaneous side effects caused by antineoplastic chemotherapy, with emphasis on skin, nails, and mucous membranes, while highlighting potential severity and the possibility of needing to adjust or interrupt treatment in rare cases; it presents no new clinical results.
April 2023 in “Research Square (Research Square)” This study found that lower GPX4 mRNA levels in polymorphonuclear neutrophils of systemic lupus erythematosus patients were negatively associated with disease activity and serological markers, suggesting a diagnostic value for GPX4 mRNA.
212 citations
,
January 2017 in “Mediators of Inflammation” This review examines current treatments and the potential role of stem cells in cutaneous wound healing, but it presents no new clinical results and calls for more research on mechanisms.
139 citations
,
February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.
105 citations
,
December 2017 in “Journal of Biological Engineering” This review discusses the challenges of skin graft acceptance and examines current strategies and alternatives for full-thickness skin replacement and repair, noting that immunological rejection remains a significant hurdle.
41 citations
,
February 2001 in “Current pharmaceutical design” This review discusses current and potential treatments for alopecia areata, focusing on immunosuppressive and immunomodulatory approaches, but provides no new clinical results.
37 citations
,
November 2003 in “Veterinary pathology” This study showed that in C3H/HeJ mice, focal follicular inflammation starts before overt hair loss, with inflammation severity possibly reaching a threshold causing hair follicle dystrophy prior to visible hair loss.
15 citations
,
March 2016 in “The American Journal of Dermatopathology” In this study, Demodex mites were infrequently found in scalp biopsies performed for hair loss, and most cases were nonpathogenic, but a minority showed folliculitis with a strong response to metronidazole therapy.
3 citations
,
July 2023 in “Biomolecules” This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.
May 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that hair with lower levels of keratin associated proteins reduced the foreign body response in mouse subcutaneous implant tests compared to hair with higher keratin levels.
February 2008 in “Experimental dermatology” This article reviews potential pathomechanisms of vitiligo, emphasizing membrane alterations involving cholesterol and cardiolipin, but reports no new clinical findings.
1 citations
,
January 2024 in “Cellular & Molecular Biology Letters” This review evaluated the potential of adipose-derived stem cells (ADSCs) for burn treatment, finding promising regenerative healing effects, though most findings are at early experimental stages primarily in animal models.
1160 citations
,
November 2018 in “Physiological Reviews” This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
156 citations
,
August 2016 in “Journal of controlled release” This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.