This review critically analyzes recent literature on the use of nanotechnology in alopecia treatment, reporting promising results for improving drug delivery and hair growth, though challenges in maintaining physical stability may limit large-scale commercialization.
January 2016 in “Journal of Materials Chemistry B” Advancements in biomaterials and nanotechnology are improving medical applications like hair growth, bone regeneration, and cancer treatment.
June 2015 in “Biomedical and biopharmaceutical research” This article reviews EU cosmetic product claim regulations and highlights increased harmonization and enforcement while reporting no new results.
January 2024 in “Journal of cosmetic dermatology” This study found that Silibinin-loaded polymeric micelles significantly protected human hair from UV-B induced structural and chemical damage by preventing increases in roughness and reducing protein loss.
13 citations
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November 2022 in “Biomaterials Science” This study demonstrated that a device combining hyaluronic acid-based dissolving microneedles and lipid polymer hybrid nanoparticles effectively delivered miR-218 to promote hair growth in a shaved mouse model, outperforming topical smear treatment without safety concerns.
1 citations
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January 2001 in “Journal of Toxicology-cutaneous and Ocular Toxicology” This review discusses the roles of hair follicles and sebaceous glands in percutaneous transport and reports no new results, noting a lack of adequate models and methodologies.
December 2024 in “Revista Eletrônica Perspectivas da Ciência e Tecnologia - ISSN 1984-5693” This study reports that delivering alopecia medications like minoxidil, finasteride, and spirinolactone via polymeric nanoparticles may improve their effectiveness by enhancing drug delivery to hair follicles, especially in cases where hair loss is linked to stress and immune changes post-COVID-19 infection.
March 2024 in “Journal of pharmacy & pharmaceutical sciences” This review discusses the design strategies and applications of long-acting polymeric microneedles, noting their potential to improve patient compliance and reduce side effects in chronic disease management, but reports no new experimental results.
June 2026 in “ACS Applied Polymer Materials” This study reports a method for fabricating biofunctional polymer fibers by using DNA-programmable cell-free protein synthesis integrated through solution blow spinning, enabling in situ protein production and potential applications in respirators, sampling swabs, and other advanced materials.
78 citations
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October 2020 in “Experimental Dermatology” This review summarizes 15 years of clinical and experimental research advancements in hidradenitis suppurativa, highlighting its recognition as a uniquely healable inflammatory skin disease but reports no new clinical results.
12 citations
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April 2023 in “Pharmaceutics” This review covers the current and potential medical uses of semifluorinated alkanes, including applications in eye surgery, drug delivery, and oxygen transport.
March 2005 in “International Journal of Cosmetic Science” This paper discusses the use of Digital Volumetric Imaging with fluorescent dyes to visualize and compare the interior structures of six different virgin hair types, reporting no new clinical results.
130 citations
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August 2020 in “Drug Design Development and Therapy” This review discusses various nanoparticles used to enhance skin permeation and target delivery to skin organelles, but reports no new experimental results.
70 citations
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August 2020 in “Nanomaterials” This review discusses the development of electrospun nanofibrous scaffolds for promoting angiogenesis in tissue engineering but notes that their clinical application beyond bone and skin repair is still limited.
60 citations
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July 2020 in “ACS Nano” This review discusses the progress and challenges in delivering CRISPR/Cas9 systems for in vivo genome editing, highlighting current methods and opportunities for future therapeutic applications.
52 citations
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January 2020 in “Scientific Reports” This study found that nanostructured lipid carriers with clobetasol propionate significantly enhance follicular drug delivery compared to commercial cream, and manual massage further doubles follicular retention.
33 citations
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November 2020 in “AAPS PharmSciTech”
30 citations
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December 2019 in “PLoS ONE” This study found that formulating raloxifene in nano-lipid carriers significantly enhanced its permeation and cytotoxicity against cancer cells compared to raw raloxifene.
28 citations
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November 2020 in “Journal of Controlled Release” In this study, microneedles combined with finasteride nanostructured lipid carriers (FIN-NLC-MNs) were found to enhance skin penetration and specifically target hair follicles, promoting hair growth and gene regulation in androgenetic alopecia.
28 citations
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September 2020 in “Pharmaceutics” This review discusses the potential of three-dimensional printed mesoporous scaffolds for drug delivery applications, particularly for bone cells and tissues, but reports no new clinical results.
4 citations
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August 2023 in “Materials” This review highlights that synthetic biodegradable polymers like PVA, PCL, PLA, PLGA, PU, and PEO/PEG can address the limitations of natural polymers in wound healing, offering improved mechanical properties and slower degradation, thereby enhancing their application as wound dressings.
2 citations
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August 2023 in “Life” This review highlights the transformative potential of bioinspired polymers in biomedical engineering, focusing on their roles in enhancing tissue engineering, regenerative medicine, and other biomedical applications, with innovations including mimicking the extracellular matrix, self-healing, antibacterial properties, and cancer therapy.
1 citations
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May 2022 in “Pharmaceutics” This study found that a developed nanostructured lipid carrier formulation of tea seed oil can effectively stimulate hair growth and reduce the oily feeling associated with direct application.
1 citations
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October 2018 in “InTech eBooks” This chapter reviews ethosomes for targeted drug delivery to the scalp in androgenetic alopecia and reports no clinical results; the authors emphasize reducing systemic side effects.
June 2026 in “International Journal of Drug Delivery Technology” This review explores the potential of herbal therapies and modern delivery methods for managing premature hair greying, highlighting promising plant-based treatments and emphasizing the need for clinical trials to validate their effectiveness.
October 2025 in “Journal of Drug Delivery Science and Technology” This study suggests that combining scalp cooling with resveratrol-loaded nanoparticles effectively protects hair follicles from chemotherapy-induced damage, highlighting a potential method to prevent hair loss during cancer treatment.
August 2023 in “International Journal of Molecular Sciences” This review highlights that liposomes offer a promising method for delivering CRISPR/Cas9 components for precise and efficient genetic modifications, with potential applications in correcting genetic diseases and enhancing immune cell function.
January 2020 in “Der Pharmacia Lettre” This review discusses natural remedies and nanoparticle formulations for alopecia management and reports no new clinical results, emphasizing potential benefits of herbal treatments over synthetic therapies.
January 2016 in “Springer eBooks” New materials and methods could improve skin healing and reduce scarring.
119 citations
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March 2020 in “Frontiers in Bioengineering and Biotechnology” This review provides an overview of recent tissue engineering and regenerative medicine developments in Asia, highlighting significant advances, representative research achievements, and discussing future directions, without presenting new research results.