17 citations
,
August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.
19 citations
,
March 2016 in “Frontiers in Plant Science” This study identified that spermidine-mediated activation of eIF5A by hypusination plays a significant role in Arabidopsis thaliana growth, flowering time, stress adaptation, and development, including changing root and aerial architecture.
May 2024 in “Brain disorders” In this animal study, agmatine exhibited a protective effect against seizures related to hormone fluctuations, with results suggesting that its anticonvulsant properties may involve interactions with central neurosteroids in female rats experiencing progesterone withdrawal.
5 citations
,
January 2004 in “Journal of applied polymer science” This study found that adding urea to a polyethyleneimine solution improved the coloring ability and color fastness of low-temperature hair dyeing with acid dye by enhancing dye penetration into the hair.
This review discusses recent advances in polydopamine-based biomaterials and their growing potential in personalized medicine, but reports no new experimental results; the authors highlight both opportunities and challenges for future applications.
May 2024 in “Nano letters” This study developed a quercetin-encapsulated and polydopamine-integrated nanosystem that reshapes the perifollicular microenvironment, showing potential for rescuing hair follicle viability and regenerating hair follicles in androgenic alopecia by scavenging reactive oxygen species and promoting angiogenesis.
3 citations
,
April 2015 in “Current problems in dermatology” This study focuses on improving the detection and characterization of an enzyme in guinea pig hair follicles that converts arginine to citrulline, highlighting challenges with assay sensitivity and reproducibility.
September 2025 in “Science Advances” This study reports that PADI4, an enzyme involved in posttranslational protein modifications, regulates progenitor cell transitions in hair follicle development by repressing transcription and interacting with translational and ribosomal processes.
125 citations
,
February 1971 in “Biochemistry” Specific cross-linkages help make hair proteins stable and strong.
63 citations
,
February 2017 in “ACS biomaterials science & engineering” In this study, polydopamine emerged as a safe and effective alternative to traditional hair dyes like PPD for dyeing gray hair permanently, showing resistance to detergents and causing less toxicity and hair loss in mice.
6 citations
,
October 2015 in “Experimental dermatology” This study found that adenine supplementation in cultured human follicle dermal papilla cells stimulated proliferation and reduced senescence, possibly through AMPK activation and increased cellular NAD+ levels.
1 citations
,
December 2011 in “EFSA Journal” This opinion from the EFSA Panel concludes that the health claim regarding spermidine prolonging the anagen phase of the hair cycle does not meet regulatory criteria as it is related to disease treatment.
12 citations
,
July 2017 in “International Journal of Cosmetic Science” This study found that N‐AOHPA was particularly effective as a silicone emulsifier for improving the condition of damaged hair by preventing amino acid dissolution from bleached hair.
5 citations
,
December 2021 in “Frontiers in Cell and Developmental Biology” This review outlines how peptidyl arginine deiminases (PADIs) and protein citrullination are involved in hair follicle regeneration and inflammatory alopecia, but presents no new clinical findings.
November 2025 in “Advanced Science” In this study, researchers developed a polyphenol–amino acid nanozyme capable of controlled hydrogen peroxide delivery, which effectively activated hair follicles via oxidative stress in a mouse model, suggesting a potential non-pharmacological treatment for alopecia.
88 citations
,
July 1958 in “Nature” This study reported the first known occurrence of citrulline in an animal protein, specifically in the fibrous protein of hair follicle inner root sheaths.
5 citations
,
October 2007 in “PubMed” This study discusses the effects of incorporating various amino acids in hair care products, noting improvements in hair surface properties and color retention when integrated with conditioners.
45 citations
,
January 1977 in “Advances in experimental medicine and biology” Hair follicles have an enzyme that converts arginine to citrulline in proteins.
1 citations
,
January 1998 in “Cosmetics and toiletries” Both amodimethicone and dimethicone copolyol amine are effective hair conditioners.
52 citations
,
May 2011 in “Journal of Neuroendocrinology” This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.
62 citations
,
December 2007 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that enzymatic conversion of Arg-51 in S100A3 protein to citrulline promotes homotetramer assembly, potentially increasing Ca²⁺ binding required for hair cuticular barrier formation.
14 citations
,
November 2013 in “Journal of the American Society for Horticultural Science” This study observed that glycine inhibited root growth and stimulated root hair development in habanero pepper seedlings, with ethylene signaling suggested to mediate these effects.
1 citations
,
January 1996 This study found that cysteine and arginine are crucial for hair growth in hair follicles, with cysteine affecting hair fibre diameter and arginine involved in protein incorporation and energy metabolism.
1 citations
,
January 1971 in “Acta dermato-venereologica” Mice hair follicles take in the amino acid cystine.
4 citations
,
December 2014 in “European Journal of Chemistry” This study synthesized and characterized new 2-hydroxypyrrolidine/piperidine derivatives using FeCl₃·6H₂O as a catalyst, but it reports no biological or clinical results.
15 citations
,
August 1991 in “American Journal of Medical Genetics” This study observed that a low-protein, arginine-supplemented diet improved the abnormal hair appearance in untreated patients with argininosuccinic aciduria.
13 citations
,
April 1982 in “The Journal of Dermatology” This study found that poly(adenosine diphosphate-ribose) synthesis in human skin varies by cell type and condition, with distinct patterns in psoriatic, cancerous, and normal tissues.
This review discusses the role of norepinephrine release and protein kinase C activation in the development of benign prostatic hypertrophy, suggesting potential targets for new therapies, but it reports no new clinical results.
16 citations
,
April 2021 in “Plant Signaling & Behavior” This study found that in Arabidopsis, the MYB30-EIN3 module plays a role in adapting root hair development to phosphate deficiency, potentially enhancing phosphate uptake from soil.
4 citations
,
January 1988 in “Cosmetics and toiletries” 0.1% piroctone olamine in hair tonics effectively treats dandruff.