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This report describes a neurometabolic disorder linked to gain-of-function variants in the ODC1 gene, characterized by developmental delay, ectodermal abnormalities, and notable facial and neuroimaging features.

In this study, severe hair loss occurred in PKC epsilon transgenic mice treated with DFMO during skin tumor prevention, highlighting a link between polyamine biosynthesis, hair follicle maintenance, and metastasis suppression.

This study found that ornithine decarboxylase expression is linked to cell proliferation and differentiation in hair follicle development and growth.

In this study, topical application of α-methylspermidine during the telogen phase in mice induced hair growth by increasing the polyamine pool and mimicking the anagen phase's characteristics.

This study observed that applying polyamines to the skin of hairless mice stimulates thymidine incorporation, suggesting polyamines may play a role in DNA synthesis control in the epidermis.

This study reported that certain minoxidil conjugates, specifically those with spermine, methylenedianiline, and diaminofluorene, were able to induce differentiation in HL-60 acute myeloid leukemia cells without toxicity at a concentration of 10 μM.

This review discusses the potential enhanced effectiveness of combining Eflornithine cream with laser or light-based systems for facial hair removal and emphasizes the need for safer and more satisfactory solutions.

This study found that overexpression of antizyme in MEK-activated transgenic mice reduced skin tumor development and restored normal differentiation of keratinocyte progenitor cells, highlighting the role of polyamines in keratinocyte biology.

In this study, Maas-Szabowski and Szabowski revealed that c-Jun and JunB transcription factors, as well as granulocyte macrophage-colony stimulating factor, regulate human keratinocyte growth and differentiation in fibroblast–keratinocyte interactions.

This study found that overexpression of ornithine decarboxylase and activated Ha-ras together led to a high rate of tumor development in a mouse model without additional carcinogens.

This study fabricated a polyamide fiber containing amber particles and characterized its potential for textile applications, noting that the chemical structure of amber remained unchanged after grinding and integration.

This article discusses various forms of alopecia and introduces Biofibre® as a current technique for addressing hair loss, without reporting new clinical results.

This study reports that newly diagnosed patients with Bachmann-Bupp syndrome exhibit a broader phenotype than previously documented, including late-onset seizures, and suggests a possible universal biochemical mechanism involving elevated ODC activity.

This study observed varying levels of polyamines in different compartments of rat hair follicles, indicating their potential involvement in hair growth, especially in the matrix and inner root sheath layers.

This study describes a capillary GC method for accurately measuring spermidine levels in hair lotions, confirming its precision and specificity for this application.

This study found that a new analytical approach revealed an increased brain pregnenolone level following finasteride treatment in a mouse model, suggesting potential for improved understanding of neurosteroid roles in brain excitability.

This study used a zebrafish model and advanced mass spectrometry to identify 11 metabolites of epristeride, revealing significant effects on purine metabolism and aromatic amino acid biosynthesis, which may aid in developing anti-doping detection methods.

This study used proteomic techniques to analyze human hair proteins, revealing keratin heterogeneity and identifying posttranslational modifications, such as cysteine trioxidation and methylation.

This study developed a validated method using UPLC-MS/MS to analyze 37 hormones in human hair, enabling broader hormonal profiling for identifying endocrine disorders.

This study demonstrated the development of high-density protein microarrays allowing for antibody binding characterization and serum profiling from patients with autoimmune diseases, suggesting potential for diagnostic marker discovery.

This study suggests that women with polycystic ovary syndrome may have a distinct metabolomic profile, differing in levels of amino acids, organic acids, and lipids compared to controls.

This study reported that mice with more diverse gut microbiota showed higher hair levels of certain hormones and 1-AG compared to those with less diverse microbiota, though plasma differences were more complex and varied by stress and sex.

This study describes how shotgun proteomics can identify over 300 proteins in hair shafts, potentially allowing for the diagnosis of diseases through noninvasive human proteome sampling.

This study developed a reliable RP-HPLC-DAD method, finding that amino acid concentrations in bleached hair decrease with higher hydrogen peroxide levels, notably affecting cystine.

This study developed and validated a comprehensive method using mass spectrometry to profile sex (pro)hormones in plasma, with results showing reliable calibration and detection of 31 analytes in samples from pre- and postmenopausal women and men, while addressing potential over- or underestimations in analyte concentrations.

This study focuses on improving the detection and characterization of an enzyme in guinea pig hair follicles that converts arginine to citrulline, highlighting challenges with assay sensitivity and reproducibility.

This study developed a new method using ultrahigh-power sonication and mass spectrometry to improve protein extraction from hair shafts, identifying 239 differentially expressed proteins related to fetal growth restriction, which were validated as potential noninvasive biomarkers for perinatal diagnostics.

Method detects finasteride in plasma and semen with high sensitivity and accuracy.

This study developed and validated a highly sensitive method using ultrahigh-performance liquid chromatography with tandem mass spectrometry for accurately analyzing nine neuroactive steroids in human serum, which could enhance understanding of disease pathophysiology and support new biomarker and therapeutic discovery.